MA1-24653 detects Eotaxin 2 from human samples.
MA1-24653 has been successfully used in inhibition and neutralization assays, and Western blot procedures. The Neutralization Dose50 (ND50) for this antibody is approximately 1 to 5 µg/mL in the presence of 100 ng/mL of recombinant human eotaxin 2, measuring the chemotaxis of rat myeloid Y3 cells transfected with the human CCR3 gene.
The MA1-24653 immunogen is purified, recombinant human eotaxin 2, expressed in E. coli.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Eotaxin is a 74-amino acid, eosinophil-chemotactic CC chemokine originally found in bronchoalveolar lavage fluid from allergic inflammatory subjects. It is involved in regulating the recruitment and activation of inflammatory leukocytes, particularly eosinophils. Eotaxin binds and activates the CCR3 chemokine receptor, and may play a fundamental role in the development of allergic responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-C motif chemokine 24; chemokine (C-C motif) ligand 24; CK-beta-6; Ckb-6; Eosinophil chemotactic protein 2; Eotaxin-2; MPIF-2; MPIF2; Myeloid progenitor inhibitory factor 2; SCYA24; small inducible cytokine subfamily A (Cys-Cys), member 24; Small-inducible cytokine A24
Gene Aliases: CCL24; Ckb-6; MPIF-2; MPIF2; SCYA24
UniProt ID: (Human) O00175
Entrez Gene ID: (Human) 6369