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|Tested species reactivity||Human , Mouse , Chicken|
|Published species reactivity||Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||A synthetic peptide derived from the C-terminus human EphA4 receptor protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The Ephrin receptor EphA4 restricts axonal sprouting and enhances branching in the injured mouse optic nerve.
37-1600 was used in western blot to investigate the role of EphA4 and EphrinA3 in adult axon regeneration using a model of adult mouse optic nerve injury
|Joly S,Jordi N,Schwab ME,Pernet V||The European journal of neuroscience (40:3021)||2014|
Modifying expression of EphA4 and its downstream targets improves functional recovery after stroke.
37-1600 was used in western blot to test if EphA4 affects stroke recovery and evaluate Eph44 as a therapeutic target.
|Lemmens R,Jaspers T,Robberecht W,Thijs VN||Human molecular genetics (22:2214)||2013|
EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans.
37-1600 was used in western blot to elucidate the role of Epha4 in models of amyotrophic lateral sclerosis.
|Van Hoecke A,Schoonaert L,Lemmens R,Timmers M,Staats KA,Laird AS,Peeters E,Philips T,Goris A,Dubois B,Andersen PM,Al-Chalabi A,Thijs V,Turnley AM,van Vught PW,Veldink JH,Hardiman O,Van Den Bosch L,Gonzalez-Perez P,Van Damme P,Brown RH,van den Berg LH,Robberecht W||Nature medicine (18:1418)||2012|
Activation of EphA receptors mediates the recruitment of the adaptor protein Slap, contributing to the downregulation of N-methyl-D-aspartate receptors.
37-1600 was used in immunohistochemistry to investigate the role of Src-like adaptor protein in the context of NMDA receptor signaling
|Semerdjieva S,Abdul-Razak HH,Salim SS,Yáñez-Muñoz RJ,Chen PE,Tarabykin V,Alifragis P||Molecular and cellular biology (33:1442)||2013|
AI385584, Cek8, Sek, 2900005C20Rik, Sek1, Hek8, TYRO1, rb, Tyro1, SEK, HEK8
ephrin type-A receptor 4, tyrosine-protein kinase receptor MPK-3, tyrosine-protein kinase receptor SEK-1, Cek8, EK8, EPH-like kinase 8, TYRO1 protein tyrosine kinase, receptor protein-tyrosine kinase HEK8, tyrosine-protein kinase TYRO1, tyrosine-protein kinase receptor SEK, HEK8, SEK, TYRO1