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MA5-15457 targets EphA7 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.
The MA5-15457 immunogen is purified recombinant fragment of EphA7 (aa27-210) expressed in E. Coli.
EPHA7 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA7 is involved in embryonic development. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
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Protein Aliases: EHK-3; EK11; epa7; EPH homology kinase 3; Eph homology kinase-3; EPH-like kinase 11; EPHA7-S; Ephrin type-A receptor 7; receptor protein-tyrosine kinase HEK11; tyrosine-protein kinase receptor EHK-3
Gene Aliases: EHK-3; EHK3; EK11; EPHA7; HEK11
UniProt ID: (Human) Q15375
Entrez Gene ID: (Human) 2045
Molecular Function: transmembrane signal receptor