MA5-15385 targets EhpB1 in IHC and WB applications and shows reactivity with Human samples.
The MA5-15385 immunogen is purified recombinant fragment of EphB1 (aa19-133) expressed in E. Coli.
MA5-15385 detects EhpB1 which has a predicted molecular weight of approximately 110kDa.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase family. The protein encoded by this gene is a receptor for ephrin-B family members.
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Protein Aliases: EK6; ELK; EPH tyrosine kinase 2; EPH-like kinase 6; EPHB1; Ephrin type-B receptor 1; EPHT2; FLJ37986; Hek6; NET; Neuronally-expressed EPH-related tyrosine kinase; soluble EPHB1 variant 1; Tyrosine-protein kinase receptor EPH-2
Gene Aliases: ELK; EPHB1; EPHT2; HEK6; NET
UniProt ID: (Human) P54762
Entrez Gene ID: (Human) 2047