MA5-15385 targets EhpB1 in IHC and WB applications and shows reactivity with Human samples.
The MA5-15385 immunogen is purified recombinant fragment of EphB1 (aa19-133) expressed in E. Coli.
MA5-15385 detects EhpB1 which has a predicted molecular weight of approximately 110kDa.
ephB1, previously known as Elk(eph-like kinase), is a receptor tyrosine kinase of the highly tissue restricted family of eph proteins. EphB1 and other ephB family members are type 1 membrane spanning proteins, comprised of immunoglobulin, fibronectin type III, and cysteine rich subdomains in the ecto domain, and the single uninterrupted cytoplasmic tyrosine kinase domain upstream of a carboxyterminal sterile alpha motif (SAM) domain. ephB family proteins bind ephrins of the B class, ligands that are also transmembrane spanning proteins capable of transmitting signals. ephB1 is expressed predominantly in developing neural structures in embryos, and in vascular epithelium of kidney, and other tissues. Upon binding to alternatively oligomerized ephrin B1, ephB1 signals regulation of cell attachment and cellcell assembly. Members of this protein family are implicated in neuronal and vascular cell targeting.
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Protein Aliases: CAPB; DRT; EK6; ELK; EPH tyrosine kinase 2; EPH-like kinase 6; EPHB3; Ephrin B1; Ephrin B2; Ephrin B3; Ephrin B4; Ephrin type-B receptor 1; EphrinB1; EphrinB2; EphrinB3; EphrinB4; EPHT3; ETK2; FLJ37986; HEK-6; HEK2; Hek5; MGC87492; NET; Neuronally-expressed EPH-related tyrosine kinase; PCBC; soluble EPHB1 variant 1; Tyro5; TYRO6; Tyrosine-protein kinase receptor EPH-2
Gene Aliases: ELK; EPHB1; EPHT2; HEK6; NET
UniProt ID: (Human) P54762
Entrez Gene ID: (Human) 2047