The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date. While the biological activities of these receptors have yet to be determined, there is increasing evidence that they are involved in central nervous system function and in development. The Eph subfamily receptors of human origin (and their murine/avian homologs) include EphA1 (Eph), EphA2 (Eck), EphA3 (Hek4), EphA4 (Hek8), EphA5 (Hek7), EphA6 (Hek12), EphA7 (Hek11/MDK1), EphA8 (Hek3), EphB1 (Hek6), EphB2 (Hek5), EphB3 (Cek10, Hek2), EphB4 (Htk), EphB5 (Hek9) and EphB6 (Mep). Ligands for Eph receptors include ephrin-A4 (LERK-4) which binds EphA3 and EphB1. In addition, ephrin-A2 (ELF-1) has been described as the ligand for EphA4, ephrin-A3 (Ehk1-L) as the ligand for EphA5 and ephrin-B2 (Htk-L) as the ligand for EphB4 (Htk).
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Protein Aliases: CAPB; Developmental kinase 5; Developmentally-regulated Eph-related tyrosine kinase; EK2; EK5; EK6; ELK; ELK-related tyrosine kinase; Embryonic kinase 2; EPH tyrosine kinase 2; EPH tyrosine kinase 3; EPH-like kinase 2; EPH-like kinase 5; EPH-like kinase 6; EPH-like tyrosine kinase 2; EPHB2, Ephrin type-B receptor 1; EphB2/CTF1; EphB2/CTF2; EPHB3, DRT; Ephrin type-B receptor 1; Ephrin type-B receptor 2; Ephrin type-B receptor 3; EPHT3; ERK; ETK2; HEK2; Hek5; human embryo kinase 2; mDK-5; MGC87492; NET; NET, HEK-6, ELK, Ephrin type-B receptor 2, Ephrin type-B receptor 3, Ephrin B1, EphrinB1, EphrinB3, Ephrin B3, Ephrin B2, EphrinB2; Neural kinase; Neuronally-expressed EPH-related tyrosine kinase; Nuk receptor tyrosine kinase; PCBC; protein-tyrosine kinase HEK5; Renal carcinoma antigen NY-REN-47; soluble EPHB1 variant 1; Tyro5; TYRO6; Tyrosine-protein kinase receptor EPH-2; Tyrosine-protein kinase receptor EPH-3; Tyrosine-protein kinase receptor SEK-3; Tyrosine-protein kinase receptor SEK-4; Tyrosine-protein kinase TYRO5; Tyrosine-protein kinase TYRO6
Gene Aliases: 9330129L11; AW456895; AW488255; C130099E04Rik; CAPB; Cek10; Cek5; Cek6; DRT; EK2; EK5; ELK; Elkh; ENSMUSG00000074119; EPHB1; EPHB2; EPHB3; EPHT2; EPHT3; EPTH3; ERK; ETECK; ETK2; HEK2; HEK5; HEK6; MDK5; NET; Nuk; PCBC; Prkm5; Qek5; Sek3; Sek4; TYRO5; TYRO6