Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.
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Protein Aliases: Developmentally-regulated Eph-related tyrosine kinase; EFL6; EFNB3; EK5; ELK-related tyrosine kinase; EPH B2; EPH tyrosine kinase 3; EPH-like kinase 5; EphB2/CTF1; EphB2/CTF2; EPHB3; Ephrin B1; Ephrin B2; Ephrin B3; Ephrin B4; Ephrin type-B receptor 2; EphrinB1; EphrinB2; EphrinB3; EphrinB4; EPLG8; ETK2; HEK-6; HEK2; LERK8; MGC87492; protein-tyrosine kinase HEK5; Renal carcinoma antigen NY-REN-47; TYRO6; Tyrosine-protein kinase receptor EPH-3; Tyrosine-protein kinase TYRO5
Gene Aliases: CAPB; DRT; EK5; EPHB2; EPHT3; EPTH3; ERK; HEK5; PCBC; TYRO5
UniProt ID: (Human) P29323
Entrez Gene ID: (Human) 2048
Molecular Function: transmembrane signal receptor