MA5-15394 targets EphB3 in IHC and WB applications and shows reactivity with Human samples.
The MA5-15394 immunogen is purified recombinant fragment of EphB3 (aa39-212) expressed in E. Coli.
MA5-15394 has been successfully used in immunohistochemistry analysis of Ephb3 in mouse E16.5 frozen lung sections.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase family. This gene encodes a receptor for ephrin-B family members.
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Protein Aliases: Developmental kinase 5; EK2; Embryonic kinase 2; EPH-like kinase 2; EPH-like tyrosine kinase 2; EPHB3; Ephrin type-B receptor 3; ETK2; HEK2; human embryo kinase 2; mDK-5; TYRO6; Tyrosine-protein kinase receptor SEK-4; Tyrosine-protein kinase TYRO6
Gene Aliases: AW456895; Cek10; EK2; EPHB3; ETK2; HEK2; MDK5; Sek4; TYRO6