37-1800 has been successfully used in Western Blot, immunohistochemical, immunofluorescence, ELISA and immunoprecipitation assays. By western blot this antibody detects a ~125kDa protein representing EPHB4 in MCF7, HT-29 and U2OS lysate.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CAPB; DRT; EPHB2; EPHB3; Ephrin B1; Ephrin B2; Ephrin B3; Ephrin B4; ephrin receptor EphB4; Ephrin type-B receptor 4; EphrinB1; EphrinB2; EphrinB3; EphrinB4; EPHT3; ERK; ETK2; HEK-6; HEK2; Hek5; Hepatoma transmembrane kinase; MGC87492; PCBC; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; Tyro5; TYRO6; tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase TYRO11
Gene Aliases: EPHB4; HTK; MYK1; TYRO11
UniProt ID: (Human) P54760
Entrez Gene ID: (Human) 2050
Molecular Function: transmembrane signal receptor