Epsin2 plays a role in the formation of clathrin-coated invaginations and endocytosis. It binds to EPS15 (via the NPF repeat domain), as well as to AP-2 and clathrin (via the DPW repeat domain). The protein resides in the cytoplasm, in punctate structures throughout the cell, associated with clathrin-coated vesicles, and is particularly concentrated in the region of the Golgi complex. Highest expression is found in brain, with lower levels detected in lung and liver.
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Protein Aliases: EH domain binding protein epsin 2; EHB21; EPS-15-interacting protein 2; Eps15 binding protein; epsin 2; Epsin-2
Gene Aliases: EHB21; EPN2; KIAA1065
UniProt ID: (Human) O95208