Associations of ErbB2, beta1-integrin and lipid rafts on Herceptin (Trastuzumab) resistant and sensitive tumor cell lines.
Mocanu MM,Fazekas Z,Petrás M,Nagy P,Sebestyén Z,Isola J,Tímár J,Park JW,Vereb G,Szöllosi J
MA5-12867 was used in flow cytometry to compare ErbB2/beta-1 integrin/lipid raft interactions in cancer cells resistant and sensitive to Herceptin
Wed Sep 28 00:00:00 EDT 2005
Isolation of scFvs to in vitro produced extracellular domains of EGFR family members.
Cancer biotherapy & radiopharmaceuticals
Horak E,Heitner T,Robinson MK,Simmons HH,Garrison J,Russeva M,Furmanova P,Lou J,Zhou Y,Yuan QA,Weiner LM,Adams GP,Marks JD
MA5-12867 was used in flow cytometry to develop and characterize specific antibodies targeting EGFR family
Thu Dec 01 00:00:00 EST 2005
Cooperative interactions of HER-2 and HPV-16 oncoproteins in the malignant transformation of human mammary epithelial cells.
Neoplasia (New York, N.Y.)
Woods Ignatoski KM,Dziubinski ML,Ammerman C,Ethier SP
MA5-12867 was used in immunoprecipitation to investigate the interaction between HER-2 and HPV-16 in human mammary epithelial cells during malignant transformation
Mon Aug 01 00:00:00 EDT 2005
HER-2/neu overexpression increases the viable hypoxic cell population within solid tumors without causing changes in tumor vascularization.
Molecular cancer research : MCR
Dragowska WH,Warburton C,Yapp DT,Minchinton AI,Hu Y,Waterhouse DN,Gelmon K,Skov K,Woo J,Masin D,Huxham LA,Kyle AH,Bally MB
MA5-12867 was used in flow cytometry to study the role of HER-2/neu overexpression in increasing the viable hypoxic cell population within solid tumors
Mon Nov 01 00:00:00 EST 2004
Alpha6beta1 integrin induces proteasome-mediated cleavage of erbB2 in breast cancer cells.
Shimizu H,Seiki T,Asada M,Yoshimatsu K,Koyama N
MA5-12867 was used in flow cytometry to study the role of alpha6beta1 integrin in inducing proteasome-mediated cleavage of erbB2 in breast cancer cells
Thu Feb 13 00:00:00 EST 2003
Proliferation-differentiation relationships in the expression of heparin-binding epidermal growth factor-related factors and erbB receptors by normal and psoriatic human keratinocytes.
Archives of dermatological research
Piepkorn M,Predd H,Underwood R,Cook P
MA5-12867 was used in immunohistochemistry to investigate the expression of heparin-binding epidermal growth factor-related factors and erbB receptors in normal and psoriatic keratinocytes
Tue Jul 01 00:00:00 EDT 2003
Anti-HER2 antibody enhances the growth inhibitory effect of anti-oestrogen on breast cancer cells expressing both oestrogen receptors and HER2.
British journal of cancer
Kunisue H,Kurebayashi J,Otsuki T,Tang CK,Kurosumi M,Yamamoto S,Tanaka K,Doihara H,Shimizu N,Sonoo H
MA5-12867 was used in flow cytometry to investigate the synergistic inhibitory effect of anti-HER2 antibody and anti-oestrogen on breast cancer cells
Sat Jan 01 00:00:00 EST 2000
Reversal of HER-2 over-expression renders human ovarian cancer cells highly resistant to taxol.
Aigner A,Hsieh SS,Malerczyk C,Czubayko F
MA5-12867 was used in flow cytometry to study the role of the HER-2 receptor in modulating the response of ovarian cancer cells to doxorubicin, cisplatin and taxol
Mon Apr 03 00:00:00 EDT 2000
Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo.
Tang CK,Concepcion XZ,Milan M,Gong X,Montgomery E,Lippman ME
MA5-12867 was used in flow cytometry to study the role of ErbB-4 in the proliferation of estrogen receptor-positive breast cancer cells
Fri Oct 15 00:00:00 EDT 1999
ErbB-4 ribozymes abolish neuregulin-induced mitogenesis.
Tang CK,Goldstein DJ,Payne J,Czubayko F,Alimandi M,Wang LM,Pierce JH,Lippman ME
MA5-12867 was used in immunocytochemistry to investigate the effect of ErbB-4 ribozymes on neuregulin-induced mitogenesis
Sat Aug 01 00:00:00 EDT 1998
Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase.
The Journal of biological chemistry
Adam L,Vadlamudi R,Kondapaka SB,Chernoff J,Mendelsohn J,Kumar R
MA5-12867 was used in western blot to study the molecular mechanisms by which heregulin regulates the reorganization of the actin cytoskeleton and cell migration
Fri Oct 23 00:00:00 EDT 1998