Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.
|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Amino acids 1-153 of human ER-ß expressed in E. coli.|
|Storage buffer||PBS, pH 7.4|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay-dependent|
|Western Blot (WB)||1-5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-23219 detects Estrogen Receptor Beta in Human samples.
MA1-23219 has been successfully used in Western Blot procedures.
MA1-23219 immunogen corresponds to Amino acids 1-153 of human ER-ß expressed in E. coli..
The human ER-beta is a newly discovered estrogen receptor initially cloned and characterized from testis. The size and structure of ER-beta is very similar to ER-alpha with the ligand and DNA binding domains being highly conserved, while the amino terminus which serves as their transactivation domain has diverged significantly. Similar in function to ER-alpha ER-beta binds to estrogen with a high affinity and regulates estrogen specific gene activation through direct interaction with estrogen response elements (ERE's).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ER Beta; ESR-Beta; ESR2; estrogen receptor 2 (ER beta); estrogen receptor beta 4; nuclear receptor subfamily 3 group A member 2
ER-BETA; Erb; ESR-BETA; ESR2; ESRB; ESTRB; NR3A2