Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
PA1-24903 detects Estrone from human samples.
PA1-24903 has been successfully used in radioimmune assay procedures.
The PA1-24903 immunogen is Estrone-6-thyroglobulin
Reconstitution add 5.0 ml of 0.05 M Tris-HCl buffer, pH 8.0, containing 0.1M sodium chloride, 0.1% gelatin and 15mM sodium azide. Rotate vial gently until powder is dissolved.
Working Solution: To obtain the number of tests indicated on the vial further dilute the reconstituted antiserum 10-fold with the buffer used to prepare the stock solution.
Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. it is converted from androstenedione directly, or from testosterone via estradiol. In humans, it is produced primarily by the cyclic ovaries, placenta, and the adipose tissue of men and postmenopausal women. Therapeutic estrone is the synthetic form of a naturally occurring estrogen estrone. Estrone diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated hormone-receptor complex gets translocated to the nucleus where it binds to the estrogen response element on the dna and promotes the transcription of target genes involved in the functioning of the female reproductive system and secondary sex characteristics. Estrone increases the hepatic synthesis of sex hormone binding globulin (shbg), thyroid-binding globulin (tbg), and other serum proteins, as well as suppresses the release of follicle-stimulating hormone (fsh) and luteinizing hormone (lh) from the anterior pituitary. [National Center for Biotechnology Information. PubChem Compound Database; CID=5870].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C18H22O2; OESTRONE
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