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|Tested species reactivity||Human|
|Published species reactivity||Hamster, Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant oncoprotein corresponding to aa 226-454 of human Ets-1|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 3 publications below|
MA5-12375 targets Ets-1 in IHC (P) applications and shows reactivity with Human samples.
The MA5-12375 immunogen is recombinant oncoprotein corresponding to aa 226-454 of human Ets-1.
Ets-1 is a transcription factor involved in the regulation of genes required for extracellular matrix remodeling during metastasis of tumors. It is known to interact with the enhancer of urokinase like plasminogen activator, and promoters of stromelysin-1 and collagenase-1. It is absent from normal gastric mucosa but is expressed in 60% of gastric carcinoma and oral squamous cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Intramucosal variant of nasal natural killer (NK)/T cell lymphoma has a better survival than does invasive variant: implication on loss of E26 transformation-specific sequence 1 (ETS-1) and T-box expressed in T cells (T-bet) with invasion.
MA5-12375 was used in immunohistochemistry to study the impact of invasion on the prognosis of nasal natural killer/T cell lymphoma
|Lin TC,Chen SU,Chen YF,Chang YC,Lin CW||Histopathology (60:287)||2012|
An immunohistochemical study of colon adenomas and carcinomas: E-cadherin, Syndecan-1, Ets-1.
MA5-12375 was used in immunohistochemistry to investigate the immunohistochemical differences between colon adenomas and carcinomas
|Pap Z,Pávai Z,Dénes L,Kovalszky I,Jung J||Pathology oncology research : POR (15:579)||2009|
Expression of ets-1 is not affected by N-ras or H-ras during oral oncogenesis.
MA5-12375 was used in immunohistochemistry to study whether the expression of ets-1 is affected by ras-activated cascades during oral oncogenesis
|Vairaktaris E,Papageorgiou G,Derka S,Moulavassili P,Nkenke E,Kessler P,Vassiliou S,Papakosta V,Spyridonidou S,Vylliotis A,Lazaris AC,Anagnostopoulou S,Mourouzis C,Yapijakis C,Patsouris E||Journal of cancer research and clinical oncology (133:227)||2007|
Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; ets protein; protein C-ets-1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1
c-ets-1; ETS-1; ETS1; EWSR2; p54