|Tested species reactivity||Human, Mouse|
|Published species reactivity||Mouse, Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant full length mouse Exo1 protein|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-12262 targets Exo1 in WB applications and shows reactivity with Human and mouse samples.
The MA5-12262 immunogen is recombinant full length mouse Exo1 protein.
The 5' to 3' double-strand DNA exonuclease (Exo1)is coded by EXO1 gene. It was identified in Saccharomyces cerevisiae as a gene encoding an exonuclease that interacts with meiosis-specific MutS homologue (MSH2) and functions in mismatch repair and genetic recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents.
MA5-12262 was used in immunoprecipitation and western blot to study the response to S(N)1 DNA methylating reagents and the role of exonuclease1 in activating the mismatch repair DNA damage response
|Izumchenko E,Saydi J,Brown KD||DNA repair (11:951)||2012|
ATR-dependent pathways control hEXO1 stability in response to stalled forks.
MA5-12262 was used in western blot to study the role of ATR-dependent pathways in controling hEXO1 stability in response to stalled forks
|El-Shemerly M,Hess D,Pyakurel AK,Moselhy S,Ferrari S||Nucleic acids research (36:511)||2008|
Degradation of human exonuclease 1b upon DNA synthesis inhibition.
MA5-12262 was used in western blot to study the regulation of human exonuclease 1b by DNA synthesis inhibition
|El-Shemerly M,Janscak P,Hess D,Jiricny J,Ferrari S||Cancer research (65:3604)||2005|