Ezrin (also known as p81, 80K, or cytovillin) is a cytoplasmic protein enriched in microvilli and other cell surface structures. Its NH2-terminal domain is associated with the plasma membrane and the COOH-terminal domain with the cytoskeleton. Ezrin has an actin-binding capability. Ezrin is expressed in epithelial cells but not in mesenchymal cells. Ezrin is also expressed by certain epithelial tumors, such as renal cell adenocarcinomas. Ezrin serves as a tyrosine kinase substrate, and is phosphorylated in EGF-stimulated cells.
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Protein Aliases: Cytovillin; cytovillin 2; epididymis secretory protein Li 105; EZRI; Ezrin; p81; VIL2; Villin 2; villin 2 (ezrin); Villin-2
Gene Aliases: AW146364; BOS_138; CVIL; CVL; EZR; HEL-S-105; p81; R75297; VIL2