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|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG2a|
|Immunogen||mouse F4/80 which is a macrophage-restricted cell surface glycoprotein.|
|Storage buffer||PBS with 4mg/ml BSA, 10% sucrose|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
EGF-Like Module Containing Mucin-Like Hormone Receptor-Like Sequence 1 (EMR1) is characterized as an Orphan-B GPCR with an unknown ligand. The C-terminus contains seven hydrophobic segments, characteristic of a G protein-coupled receptor. The N-terminus of EMR1 has 6 EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. EMR1 has been reported to be expressed in human peripheral blood mononuclear cells, monocytes, and hematopoietic and solid tumor-derived cell lines. ESTs have been isolated from human normal spleen and mixed liver/spleen libraries and from human kidney, colon, brain, and bone marrow cancer libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Cranial irradiation alters the brain's microenvironment and permits CCR2+ macrophage infiltration.
MF48005 was used in flow cytometry to
|Morganti JM,Jopson TD,Liu S,Gupta N,Rosi S||PloS one (9:null)||2014|
Sonic Hedgehog contributes to gastric mucosal restitution after injury.
MF48005 was used in flow cytometry to identify the role of Shh in gastric epithelial regeneration during wound healing.
|Xiao C,Feng R,Engevik AC,Martin JR,Tritschler JA,Schumacher M,Koncar R,Roland J,Nam KT,Goldenring JR,Zavros Y||Laboratory investigation; a journal of technical methods and pathology (93:96)||2013|
Toxoplasma gondii prevents chromatin remodeling initiated by TLR-triggered macrophage activation.
MF48005 was used in flow cytometry to study the effect of Toxoplasma gondii on chromatin remodeling
|Leng J,Butcher BA,Egan CE,Abi Abdallah DS,Denkers EY||Journal of immunology (Baltimore, Md. : 1950) (182:489)||2009|
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.
MF48005 was used in immunohistochemistry (frozen) to investigate how heme regulates Spic in macrophages.
|Haldar M,Kohyama M,So AY,Kc W,Wu X,Briseño CG,Satpathy AT,Kretzer NM,Arase H,Rajasekaran NS,Wang L,Egawa T,Igarashi K,Baltimore D,Murphy TL,Murphy KM||Cell (156:1223)||2014|
cell surface glycoprotein F4/80; EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1; EMR1 hormone receptor; F4/80; lymphocyte antigen 71; TM7LN3
Adgre1; DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480; Ly71; TM7LN3