Invitrogen

F4/80 Monoclonal Antibody (BM8), Super Bright™ 702, eBioscience™

Product Image Gallery

F4/80 Antibody in Flow Cytometry (Flow) — Staining of mouse resident peritoneal exudate cells with CD11b Monoclonal Antibody, PE (Product # 12-0112-82) and 0.5 µg of Rat IgG2a K Isotype Control, Super Bright 702 (Product # 67-4321-82) (left) or 0.5 µg of F4/80 Monoclonal Antibody, Super Bright 702 (right). Cells in the large scatter population were used for analysis.

F4/80 Antibody in Immunocytochemistry (ICC/IF) — Figure 6 Immunofluorescence staining of key proteins of the BMP4/Smad9 signaling pathway of Mo2 cells in ovarian tissue. The pathway protein refers to TGFbeta, BMP4, SMAD9, p-SMAD9 (phosphorylated SMAD9). Scale bars: 30 um.

F4/80 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Fig. 1 CLEC4F is specifically expressed by Kupffer cells in the mouse liver. A The sequencing results of Clec4f -/- mice with deletion of 4-bp ""GCGG"" in both Clec4f alleles. B Clec4f mRNA expression in the mouse liver analyzed by qRT-PCR. C CLEC4F protein levels of mouse liver lysates analyzed by western blot. D CLEC4F protein levels of different mouse tissue lysates analyzed by western blot . E Representative images of immunofluorescent staining of formalin-fixed paraffin-embedded mouse liver sections. Kupffer cell (CLEC4F, red or F4/80, green). Results are representative of at least three experiments.

F4/80 Antibody in Immunohistochemistry (Frozen) (IHC (F)) — Figure 7 DSS treatment leads to colitis and disruption of periganglionic ECM via a macrophage-dependent mechanism. Schematic drawing shows experimental design of DSS treatment and concurrent L-clodronate administration ( A ). Colonic shortening characteristic of DSS-induced colitis was observed, but not in mice receiving clodronate treatment ( B and D ). Muscularis propria was thickened in DSS-treated mice compared with controls (172 +- 11.6 vs 136.8 +- 18.8 mum, P = .003; C ) and with clodronate treated mice ( F ; 172 +- 11.6 vs 124.2 +- 15.7 mum, P = .022; C ). Radar chart shows higher disease activity index (DAI) scores in DSS versus controls (2 +- 0.8 vs 0, P < .001) and clodronate treated animals (2 +- 0.8 vs 0.4 +- 0.5, P = .003; E ). L-clodronate treatment ameliorates DSS-induced colitis based on histopathologic assessment with H&E staining ( F ). Agrin ( G ) and Col4 ( G' ) are normally expressed around the enteric ganglia but are severely disrupted after 7 days of DSS treatment ( H and H' ). DSS colitis is associated with extensive F4/80+ macrophage infiltration in the distal colon, including within the ganglia ( H, inset; H', arrowhead ). In animals treated with liposomal clodronate during DSS administration, macrophages are absent from the muscularis propria ( I-I' ). Although inflammatory signs are still present in the mucosa and lamina propria, normal ECM patterning is preserved, with intact agrin and Col4 around the ganglia ( I-I' ). DSS leads to agrin degradati

F4/80 Antibody in Immunohistochemistry, Immunohistochemistry (Frozen) (IHC, IHC (F)) — Figure 2 Immunophenotype and spatial distribution of IGMs in CX3CR1 GFP mouse colon. GFP+ IGMs are present within the agrin-bordered enteric ganglia and co-express CD11b ( A-A"" ), CSF1R ( B-B"" ), F4/80 ( C-C"" ), and Iba1 ( D-D"" ). F4/80 and Iba1 are co-expressed by MMs and IGMs ( F-F"" , arrowheads , magnified from circled area in E ), but Iba1 is not present in submucosal macrophages ( F-F"" , arrows ). In lymphatic aggregates of the colonic mucosa ( E , area within dashed line ), macrophages express Iba1 but not F4/80. Comparison of MM and IGM cell number in the proximal and distal colon of CX3CR1 GFP mice shows no significant difference in ratio of IGMs to total MMs ( G ; 3.26 % +- 1.3 % vs 2.12 % +- 1.1 %, P = .0977, n = 8). However, the number of IGMs is significantly higher in distal colon compared with proximal colon when adjusted to myenteric ganglion area ( H ; 82.37 +- 32.98 vs 50.25 +- 19.6 cell/mm 2 , P = .0309, n = 8).

F4/80 Antibody in Immunohistochemistry (IHC) — Figure 4 IL-19 expression in the liver and quantitative real-time PCR. WT and IL-19 KO mice were fed a CDAHFD diet for 9 weeks. ( A ) Representative liver sections immunohistochemically stained with IL-19 and F4/80 antibodies with DAPI are shown ( n = 4-5). Scale bar represents 50 mum. ( B ) IL-19 mRNA expression in the livers of WT mice fed an SD ( n = 5) or CDAHFD ( n = 10) diet for 9 weeks. ## p < 0.01 vs. SD. ( C ) mRNA expressions of IL-6, TNF-alpha, and TGF-beta in the livers of WT and IL-19 KO mice fed an SD ( n = 4) or CDAHFD ( n = 7) diet for 9 weeks. # p < 0.05, ## p < 0.01 vs. SD. * p < 0.05, ** p < 0.01 vs. WT.

Product Details

67-4801-82

Applications	Tested Dilution	Publications
Immunohistochemistry (IHC)	-	View 45 publications 45 publications
Immunohistochemistry (Paraffin) (IHC (P))	-	View 3 publications 3 publications
Immunohistochemistry (PFA fixed) (IHC (PFA))	-	View 1 publication 1 publication
Immunohistochemistry (Frozen) (IHC (F))	-	View 4 publications 4 publications
Immunocytochemistry (ICC/IF)	-	View 17 publications 17 publications
Flow Cytometry (Flow)	1.0 µg/test	View 57 publications 57 publications

Product Specifications
Species Reactivity	Mouse
Published species	Not Applicable
Host/Isotype	Rat / IgG2a, kappa
Recommended Isotype Control	Rat IgG2a kappa Isotype Control (eBR2a), Super Bright™ 702, eBioscience™
Class	Monoclonal
Type	Antibody
Clone	BM8
Conjugate	Super Bright™ 702 Alexa Fluor 488 Alexa Fluor 532 Alexa Fluor 561 Alexa Fluor 660 Alexa Fluor 700 APC APC-eFluor 780 Biotin Brilliant UV 395 Brilliant UV 563 Brilliant Violet 421 Brilliant Violet 650 eFluor 450 eFluor 506 eFluor 570 eFluor 660 FITC Functional Grade PE PE-Cyanine5 PE-Cyanine7 PE-eFluor 610 PerCP-Cyanine5.5 Super Bright 436 Super Bright 600 Super Brigh
Excitation/Emission Profile	View spectra
Form	Liquid
Concentration	0.2 mg/mL
Purification	Affinity chromatography
Storage buffer	PBS, pH 7.2, with BSA
Contains	0.09% sodium azide
Storage conditions	4° C, store in dark, DO NOT FREEZE!
RRID	AB_2717171

Product Specific Information

Description: The BM8 monoclonal antibody reacts with mouse F4/80 antigen, an approximately 160 kDa surface receptor. It belongs to the EGF-TM7 family of proteins. As such it contains seven EGF-like domains on its extracellular N-terminus, seven transmembrane spanning sequences, and an intracellular C-terminal domain showing homology to other TM7 superfamily members. The F4/80 antigen is expressed by a majority of mature macrophages and is one of the best markers for this population of cells. However, other cell types, such as peritoneal eosinophils, Langerhans cells, and some other dendritic cell subtypes, have been reported to express this antigen as well. Expression of F4/80 commences during early myeloid development in vivo and can be upregulated on BM cells stimulated in vitro with M-CSF. Some populations of macrophages, especially in the lymphoid microenvironment, may be devoid of F4/80.

Applications Reported: This BM8 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This BM8 antibody has been tested by flow cytometric analysis of mouse resident peritoneal exudate cells. This can be used at less than or equal to 1.0 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Super Bright 702 is a tandem dye that can be excited with the violet laser line (405 nm) and emits at 702 nm. We recommend using a 710/50 bandpass filter. Please make sure that your instrument is capable of detecting this fluorochrome.

When using two or more Super Bright dye-conjugated antibodies in a staining panel, it is recommended to use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize any non-specific polymer interactions. Please refer to the datasheet for Super Bright Staining Buffer for more information.

Light sensitivity: This tandem dye is sensitive to photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-8222) (100 µL of cell sample + 100 µL of IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 405 nm; Emission: 702 nm; Laser: Violet Laser

Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company.

Target Information

F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Flow Cytometry

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International journal of molecular sciences

Pavlović N,Kopsida M,Gerwins P,Heindryckx F

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Sat Oct 31 00:00:00 EDT 2020

Murine Fecal Microbiota Transplantation Alleviates Intestinal and Systemic Immune Responses in Campylobacter jejuni Infected Mice Harboring a Human Gut Microbiota.

Frontiers in immunology

Heimesaat MM,Mrazek K,Bereswill S

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry (Paraffin)

Mon Oct 26 00:00:00 EDT 2020

Murine Fecal Microbiota Transplantation Alleviates Intestinal and Systemic Immune Responses in Campylobacter jejuni Infected Mice Harboring a Human Gut Microbiota.

Frontiers in immunology

Heimesaat MM,Mrazek K,Bereswill S

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry (Paraffin)

Mon Oct 26 00:00:00 EDT 2020

Macrophage-Associated Lipin-1 Promotes β-Oxidation in Response to Proresolving Stimuli.

ImmunoHorizons

Schilke RM,Blackburn CMR,Rao S,Krzywanski DM,Finck BN,Woolard MD

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Mon Oct 19 00:00:00 EDT 2020

Macrophage GIT1 Contributes to Bone Regeneration by Regulating Inflammatory Responses in an ERK/NRF2-Dependent Way.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Zhao SJ,Liu H,Chen J,Qian DF,Kong FQ,Jie J,Yin GY,Li QQ,Fan J

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models.

International journal of molecular sciences

Krenacs T,Meggyeshazi N,Forika G,Kiss E,Hamar P,Szekely T,Vancsik T

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Sat Aug 29 00:00:00 EDT 2020

Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage-myofibroblast transition.

Proceedings of the National Academy of Sciences of the United States of America

Tang PM,Zhang YY,Xiao J,Tang PC,Chung JY,Li J,Xue VW,Huang XR,Chong CC,Ng CF,Lee TL,To KF,Nikolic-Paterson DJ,Lan HY

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunocytochemistry

Tue Aug 25 00:00:00 EDT 2020

Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage-myofibroblast transition.

Proceedings of the National Academy of Sciences of the United States of America

Tang PM,Zhang YY,Xiao J,Tang PC,Chung JY,Li J,Xue VW,Huang XR,Chong CC,Ng CF,Lee TL,To KF,Nikolic-Paterson DJ,Lan HY

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunocytochemistry

Tue Aug 25 00:00:00 EDT 2020

Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms.

Cells

Nuti E,Rossello A,Cuffaro D,Camodeca C,Van Bael J,van der Maat D,Martens E,Fiten P,Pereira RVS,Ugarte-Berzal E,Gouwy M,Opdenakker G,Vandooren J

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Tue Jul 07 00:00:00 EDT 2020

Spatial proteomics revealed a CX₃CL1-dependent crosstalk between the urothelium and relocated macrophages through IL-6 during an acute bacterial infection in the urinary bladder.

Mucosal immunology

Bottek J,Soun C,Lill JK,Dixit A,Thiebes S,Beerlage AL,Horstmann M,Urbanek A,Heuer H,Uszkoreit J,Eisenacher M,Bracht T,Sitek B,Hoffmann F,Vijitha N,von Eggeling F,Engel DR

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry (Frozen)

Wed Jul 01 00:00:00 EDT 2020

Spatial proteomics revealed a CX₃CL1-dependent crosstalk between the urothelium and relocated macrophages through IL-6 during an acute bacterial infection in the urinary bladder.

Mucosal immunology

Bottek J,Soun C,Lill JK,Dixit A,Thiebes S,Beerlage AL,Horstmann M,Urbanek A,Heuer H,Uszkoreit J,Eisenacher M,Bracht T,Sitek B,Hoffmann F,Vijitha N,von Eggeling F,Engel DR

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry (Frozen)

Wed Jul 01 00:00:00 EDT 2020

High-salt diet decreases mechanical thresholds in mice that is mediated by a CCR2-dependent mechanism.

Journal of neuroinflammation

Fan A,Oladiran O,Shi XQ,Zhang J

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Tue Jun 09 00:00:00 EDT 2020

Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.

eLife

Kim EH,Woodruff MC,Grigoryan L,Maier B,Lee SH,Mandal P,Cortese M,Natrajan MS,Ravindran R,Ma H,Merad M,Gitlin AD,Mocarski ES,Jacob J,Pulendran B

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Tue Jun 09 00:00:00 EDT 2020

Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice.

Liver international : official journal of the International Association for the Study of the Liver

Fuchs CD,Krivanec S,Steinacher D,Mlitz V,Wahlström A,Stahlman M,Claudel T,Scharnagl H,Stojakovic T,Marschall HU,Trauner M

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Mon Jun 01 00:00:00 EDT 2020

Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer.

Journal of hematology & oncology

Lu CS,Shiau AL,Su BH,Hsu TS,Wang CT,Su YC,Tsai MS,Feng YH,Tseng YL,Yen YT,Wu CL,Shieh GS

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

Immune-modulatory Properties of the Octapeptide NAP in Campylobacter jejuni Infected Mice Suffering from Acute Enterocolitis.

Microorganisms

Heimesaat MM,Mousavi S,Kløve S,Genger C,Weschka D,Giladi E,Bereswill S,Gozes I

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Tue May 26 00:00:00 EDT 2020

Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression.

Nature communications

Yu L,Zhang B,Deochand D,Sacta MA,Coppo M,Shang Y,Guo Z,Zeng X,Rollins DA,Tharmalingam B,Li R,Chinenov Y,Rogatsky I,Hu X

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Fri May 08 00:00:00 EDT 2020

Orf Virus IL-10 and VEGF-E Act Synergistically to Enhance Healing of Cutaneous Wounds in Mice.

Journal of clinical medicine

Wise LM,Stuart GS,Jones NC,Fleming SB,Mercer AA

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunocytochemistry

Sat Apr 11 00:00:00 EDT 2020

Spider venom administration impairs glioblastoma growth and modulates immune response in a non-clinical model.

Scientific reports

Bonfanti AP,Barreto N,Munhoz J,Caballero M,Cordeiro G,Rocha-E-Silva T,Sutti R,Moura F,Brunetto S,Ramos CD,Thomé R,Verinaud L,Rapôso C

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Fri Apr 03 00:00:00 EDT 2020

Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1.

Nature metabolism

Brett JO,Arjona M,Ikeda M,Quarta M,de Morrée A,Egner IM,Perandini LA,Ishak HD,Goshayeshi A,Benjamin DI,Both P,Rodríguez-Mateo C,Betley MJ,Wyss-Coray T,Rando TA

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Wed Apr 01 00:00:00 EDT 2020

Chronic mTOR activation induces a degradative smooth muscle cell phenotype.

The Journal of clinical investigation

Li G,Wang M,Caulk AW,Cilfone NA,Gujja S,Qin L,Chen PY,Chen Z,Yousef S,Jiao Y,He C,Jiang B,Korneva A,Bersi MR,Wang G,Liu X,Mehta S,Geirsson A,Gulcher JR,Chittenden TW,Simons M,Humphrey JD,Tellides G

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunocytochemistry

Mon Mar 02 00:00:00 EST 2020

Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury.

Journal of neuroinflammation

Kong FQ,Zhao SJ,Sun P,Liu H,Jie J,Xu T,Xu AD,Yang YQ,Zhu Y,Chen J,Zhou Z,Qian DF,Gu CJ,Chen Q,Yin GY,Zhang HW,Fan J

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunocytochemistry

Mon Feb 17 00:00:00 EST 2020

Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury.

Journal of neuroinflammation

Kong FQ,Zhao SJ,Sun P,Liu H,Jie J,Xu T,Xu AD,Yang YQ,Zhu Y,Chen J,Zhou Z,Qian DF,Gu CJ,Chen Q,Yin GY,Zhang HW,Fan J

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunocytochemistry

Mon Feb 17 00:00:00 EST 2020

Inhibitory effect of silymarin on CCl₄-induced liver fibrosis by reducing Ly6C^hi monocytes infiltration.

International journal of clinical and experimental pathology

Zhao XA,Chen GM,Liu Y,Chen YX,Wu HY,Chen J,Xiong YL,Tian C,Wang GY,Jia B,Xia J,Wang J,Yan XM,Zhang ZP,Huang R,Wu C

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Sun Jan 26 00:00:00 EST 2020

Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.

Cell reports

Blagih J,Zani F,Chakravarty P,Hennequart M,Pilley S,Hobor S,Hock AK,Walton JB,Morton JP,Gronroos E,Mason S,Yang M,McNeish I,Swanton C,Blyth K,Vousden KH

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Tue Jan 14 00:00:00 EST 2020

CTNNB1/β-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes.

Science advances

Chen M,Lu P,Ma Q,Cao Y,Chen N,Li W,Zhao S,Chen B,Shi J,Sun Y,Shen H,Sun L,Shen J,Liao Q,Zhang Y,Hong J,Gu W,Liu R,Ning G,Wang W,Wang J

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

Differential Activation of Macrophages Based on Their Environment in Advanced Age.

Chonnam medical journal

Lee DY,Lim JS,Cho KA

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

A Humanized Bone Niche Model Reveals Bone Tissue Preservation Upon Targeting Mitochondrial Complex I in Pseudo-Orthotopic Osteosarcoma.

Journal of clinical medicine

Kurelac I,Abarrategi A,Ragazzi M,Iommarini L,Umesh Ganesh N,Snoeks T,Bonnet D,Porcelli AM,Malanchi I,Gasparre G

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Wed Dec 11 00:00:00 EST 2019

1,25-Dihydroxyvitamin D Inhibits LPS-Induced High-Mobility Group Box 1 (HMGB1) Secretion via Targeting the NF-E2-Related Factor 2-Hemeoxygenase-1-HMGB1 Pathway in Macrophages.

Frontiers in immunology

Rao Z,Zhang N,Xu N,Pan Y,Xiao M,Wu J,Zhou H,Yang S,Chen Y

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunocytochemistry

Wed Nov 20 00:00:00 EST 2019

NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD.

Hepatology (Baltimore, Md.)

Ohashi K,Wang Z,Yang YM,Billet S,Tu W,Pimienta M,Cassel SL,Pandol SJ,Lu SC,Sutterwala FS,Bhowmick N,Seki E

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Fri Nov 01 00:00:00 EDT 2019

Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth.

Nature communications

Kusano T,Ehirchiou D,Matsumura T,Chobaz V,Nasi S,Castelblanco M,So A,Lavanchy C,Acha-Orbea H,Nishino T,Okamoto K,Busso N

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Mon Oct 28 00:00:00 EDT 2019

Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.

Anti-cancer drugs

Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Islet α-cell Inflammation Induced By NF-κB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice.

Theranostics

Li X,Jia L,Chen X,Dong Y,Ren X,Dong Y,Chen Y,Xie L,Liu M,Shiota C,Gittes GK,Rui L,Chen Z

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Thu Sep 05 00:00:00 EDT 2019

Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway.

EBioMedicine

Nunes NS,Chandran P,Sundby M,Visioli F,da Costa Gonçalves F,Burks SR,Paz AH,Frank JA

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Mon Jul 01 00:00:00 EDT 2019

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.

Nature

Escolano A,Gristick HB,Abernathy ME,Merkenschlager J,Gautam R,Oliveira TY,Pai J,West AP,Barnes CO,Cohen AA,Wang H,Golijanin J,Yost D,Keeffe JR,Wang Z,Zhao P,Yao KH,Bauer J,Nogueira L,Gao H,Voll AV,Montefiori DC,Seaman MS,Gazumyan A,Silva M,McGuire AT,Stamatatos L,Irvine DJ,Wells L,Martin MA,Bjorkman PJ,Nussenzweig MC

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Sat Jun 01 00:00:00 EDT 2019

Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitis.

Cell death & disease

Farooq M,Filliol A,Simoes Eugénio M,Piquet-Pellorce C,Dion S,Raguenes-Nicol C,Jan A,Dimanche-Boitrel MT,Le Seyec J,Samson M

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Tue Jan 08 00:00:00 EST 2019

Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes.

EBioMedicine

Bai J,Gao Y,Chen L,Yin Q,Lou F,Wang Z,Xu Z,Zhou H,Li Q,Cai W,Sun Y,Niu L,Wang H,Wei Z,Lu S,Zhou A,Zhang J,Wang H

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Tue Jan 01 00:00:00 EST 2019

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.

Nature

Morioka S,Perry JSA,Raymond MH,Medina CB,Zhu Y,Zhao L,Serbulea V,Onengut-Gumuscu S,Leitinger N,Kucenas S,Rathmell JC,Makowski L,Ravichandran KS

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Thu Nov 01 00:00:00 EDT 2018

Yap/Taz mediates mTORC2-stimulated fibroblast activation and kidney fibrosis.

The Journal of biological chemistry

Gui Y,Li J,Lu Q,Feng Y,Wang M,He W,Yang J,Dai C

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry (Frozen)

Fri Oct 19 00:00:00 EDT 2018

The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis.

Cell host & microbe

Truax AD,Chen L,Tam JW,Cheng N,Guo H,Koblansky AA,Chou WC,Wilson JE,Brickey WJ,Petrucelli A,Liu R,Cooper DE,Koenigsknecht MJ,Young VB,Netea MG,Stienstra R,Sartor RB,Montgomery SA,Coleman RA,Ting JP

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Wed Sep 12 00:00:00 EDT 2018

Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1.

The Journal of biological chemistry

Rijal D,Ariana A,Wight A,Kim K,Alturki NA,Aamir Z,Ametepe ES,Korneluk RG,Tiedje C,Menon MB,Gaestel M,McComb S,Sad S

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Fri Jul 27 00:00:00 EDT 2018

Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis.

EMBO molecular medicine

Youssif C,Cubillos-Rojas M,Comalada M,Llonch E,Perna C,Djouder N,Nebreda AR

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunocytochemistry

Sun Jul 01 00:00:00 EDT 2018

Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis.

EMBO molecular medicine

Youssif C,Cubillos-Rojas M,Comalada M,Llonch E,Perna C,Djouder N,Nebreda AR

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunocytochemistry

Sun Jul 01 00:00:00 EDT 2018

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Cell

Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Thu Jun 28 00:00:00 EDT 2018

BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells.

Oncotarget

Romano E,Rufo N,Korf H,Mathieu C,Garg AD,Agostinis P

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Tue Apr 03 00:00:00 EDT 2018

Sustained Delivery of Doxorubicin via Acetalated Dextran Scaffold Prevents Glioblastoma Recurrence after Surgical Resection.

Molecular pharmaceutics

Graham-Gurysh E,Moore KM,Satterlee AB,Sheets KT,Lin FC,Bachelder EM,Miller CR,Hingtgen SD,Ainslie KM

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Mon Mar 05 00:00:00 EST 2018

Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock.

Journal of leukocyte biology

Jiao Y,Li Z,Loughran PA,Fan EK,Scott MJ,Li Y,Billiar TR,Wilson MA,Shi X,Fan J

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Evaluation of renal metabolic response to partial ureteral obstruction with hyperpolarized ¹³ C MRI.

NMR in biomedicine

Niles DJ,Gordon JW,Huang G,Reese S,Adamson EB,Djamali A,Fain SB

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry (Paraffin)

Mon Jan 01 00:00:00 EST 2018

The role of human cytochrome P450 2E1 in liver inflammation and fibrosis.

Hepatology communications

Xu J,Ma HY,Liang S,Sun M,Karin G,Koyama Y,Hu R,Quehenberger O,Davidson NO,Dennis EA,Kisseleva T,Brenner DA

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Fri Dec 01 00:00:00 EST 2017

The Second-Generation PGI2 Analogue Treprostinil Fails to Chemoprevent Tumors in a Murine Lung Adenocarcinoma Model.

Cancer prevention research (Philadelphia, Pa.)

Dwyer-Nield L,Hickey GA,Friedman M,Choo K,McArthur DG,Tennis MA,New ML,Geraci M,Keith RL

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2017

Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.

PloS one

Gao SY,Zheng GS,Wang L,Liang YJ,Zhang SE,Lao XM,Li K,Liao GQ

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Mon Sep 18 00:00:00 EDT 2017

Phenotypic switch in lung interstitial macrophage polarization in an ovalbumin-induced mouse model of asthma.

Experimental and therapeutic medicine

Nie H,Wang A,He Q,Yang Q,Liu L,Zhang G,Huang Y,Ding X,Yu H,Hu S

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

(Pro)renin Receptor Is an Amplifier of Wnt/β-Catenin Signaling in Kidney Injury and Fibrosis.

Journal of the American Society of Nephrology : JASN

Li Z,Zhou L,Wang Y,Miao J,Hong X,Hou FF,Liu Y

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunocytochemistry

Tue Aug 01 00:00:00 EDT 2017

Rictor/mammalian target of rapamycin complex 2 promotes macrophage activation and kidney fibrosis.

The Journal of pathology

Ren J,Li J,Feng Y,Shu B,Gui Y,Wei W,He W,Yang J,Dai C

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunocytochemistry

Tue Aug 01 00:00:00 EDT 2017

RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.

EMBO molecular medicine

Zhu H,Lou F,Yin Q,Gao Y,Sun Y,Bai J,Xu Z,Liu Z,Cai W,Ke F,Zhang L,Zhou H,Wang H,Wang G,Chen X,Zhang H,Wang Z,Ginhoux F,Lu C,Su B,Wang H

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

One Year Follow-Up Risk Assessment in SKH-1 Mice and Wounds Treated with an Argon Plasma Jet.

International journal of molecular sciences

Schmidt A,Woedtke TV,Stenzel J,Lindner T,Polei S,Vollmar B,Bekeschus S

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Wed Apr 19 00:00:00 EDT 2017

Omega-3 Polyunsaturated Fatty Acids Attenuate Fibroblast Activation and Kidney Fibrosis Involving MTORC2 Signaling Suppression.

Scientific reports

Zeng Z,Yang H,Wang Y,Ren J,Dai Y,Dai C

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Mon Apr 10 00:00:00 EDT 2017

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.

The Journal of experimental medicine

Thomas DC,Clare S,Sowerby JM,Pardo M,Juss JK,Goulding DA,van der Weyden L,Storisteanu D,Prakash A,Espéli M,Flint S,Lee JC,Hoenderdos K,Kane L,Harcourt K,Mukhopadhyay S,Umrania Y,Antrobus R,Nathan JA,Adams DJ,Bateman A,Choudhary JS,Lyons PA,Condliffe AM,Chilvers ER,Dougan G,Smith KG

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Mon Apr 03 00:00:00 EDT 2017

PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy.

Scientific reports

Gao S,Li C,Zhu Y,Wang Y,Sui A,Zhong Y,Xie B,Shen X

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Fri Feb 17 00:00:00 EST 2017

Temporal and spatial distribution of macrophage phenotype markers in the foreign body response to glutaraldehyde-crosslinked gelatin hydrogels.

Journal of biomaterials science. Polymer edition

Yu T,Wang W,Nassiri S,Kwan T,Dang C,Liu W,Spiller KL

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Thu Dec 29 00:00:00 EST 2016

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.

Immunology

Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

NADPH Oxidases Are Essential for Macrophage Differentiation.

The Journal of biological chemistry

Xu Q,Choksi S,Qu J,Jang J,Choe M,Banfi B,Engelhardt JF,Liu ZG

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Fri Sep 16 00:00:00 EDT 2016

NADPH Oxidases Are Essential for Macrophage Differentiation.

The Journal of biological chemistry

Xu Q,Choksi S,Qu J,Jang J,Choe M,Banfi B,Engelhardt JF,Liu ZG

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Fri Sep 16 00:00:00 EDT 2016

Periostin (POSTN) Regulates Tumor Resistance to Antiangiogenic Therapy in Glioma Models.

Molecular cancer therapeutics

Park SY,Piao Y,Jeong KJ,Dong J,de Groot JF

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Thu Sep 01 00:00:00 EDT 2016

Low intensity vibration mitigates tumor progression and protects bone quantity and quality in a murine model of myeloma.

Bone

Pagnotti GM,Chan ME,Adler BJ,Shroyer KR,Rubin J,Bain SD,Rubin CT

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2016

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Thu Jun 02 00:00:00 EDT 2016

Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD.

Journal of lipid research

Chattopadhyay A,Navab M,Hough G,Grijalva V,Mukherjee P,Fogelman HR,Hwang LH,Faull KF,Lusis AJ,Reddy ST,Fogelman AM

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Recruited monocytes modulate malaria-induced lung injury through CD36-mediated clearance of sequestered infected erythrocytes.

Journal of leukocyte biology

Lagassé HA,Anidi IU,Craig JM,Limjunyawong N,Poupore AK,Mitzner W,Scott AL

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

PER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice.

Cell death & disease

Wang T,Wang Z,Yang P,Xia L,Zhou M,Wang S,Du J,Zhang J

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Thu Apr 07 00:00:00 EDT 2016

SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL.

Autophagy

Choi SH,Gonen A,Diehl CJ,Kim J,Almazan F,Witztum JL,Miller YI

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Tue Feb 23 00:00:00 EST 2016

Hedgehog signaling indirectly affects tubular cell survival after obstructive kidney injury.

American journal of physiology. Renal physiology

Rauhauser AA,Ren C,Lu D,Li B,Zhu J,McEnery K,Vadnagara K,Zepeda-Orozco D,Zhou XJ,Lin F,Jetten AM,Attanasio M

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Sun Nov 01 00:00:00 EDT 2015

Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors.

American journal of physiology. Renal physiology

Yuan A,Lee Y,Choi U,Moeckel G,Karihaloo A

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2015

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.

Nature

Colegio OR,Chu NQ,Szabo AL,Chu T,Rhebergen AM,Jairam V,Cyrus N,Brokowski CE,Eisenbarth SC,Phillips GM,Cline GW,Phillips AJ,Medzhitov R

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Thu Sep 25 00:00:00 EDT 2014

Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitis.

PloS one

Harmel-Laws E,Mann EA,Cohen MB,Steinbrecher KA

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Mon Aug 18 00:00:00 EDT 2014

VEGFR-1 blockade disrupts peri-implantation decidual angiogenesis and macrophage recruitment.

Vascular cell

Douglas NC,Zimmermann RC,Tan QK,Sullivan-Pyke CS,Sauer MV,Kitajewski JK,Shawber CJ

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Thu Aug 07 00:00:00 EDT 2014

VEGFR-1 blockade disrupts peri-implantation decidual angiogenesis and macrophage recruitment.

Vascular cell

Douglas NC,Zimmermann RC,Tan QK,Sullivan-Pyke CS,Sauer MV,Kitajewski JK,Shawber CJ

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Thu Aug 07 00:00:00 EDT 2014

The impact of Toll-like-receptor-9 on intestinal microbiota composition and extra-intestinal sequelae in experimental Toxoplasma gondii induced ileitis.

Gut pathogens

Bereswill S,Kühl AA,Alutis M,Fischer A,Möhle L,Struck D,Liesenfeld O,Göbel UB,Dunay IR,Heimesaat MM

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Mon Jun 16 00:00:00 EDT 2014

Survey of extra-intestinal immune responses in asymptomatic long-term Campylobacter jejuni-infected mice.

European journal of microbiology & immunology

Heimesaat MM,Haag LM,Fischer A,Otto B,Kühl AA,Göbel UB,Bereswill S

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Sun Sep 01 00:00:00 EDT 2013

Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy.

Science translational medicine

Mascia F,Lam G,Keith C,Garber C,Steinberg SM,Kohn E,Yuspa SH

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Wed Aug 21 00:00:00 EDT 2013

Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms.

The American journal of pathology

Ninković J,Roy S

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2012

Selective gelatinase blockage ameliorates acute DSS colitis.

European journal of microbiology & immunology

Heimesaat MM,Dunay IR,Fuchs D,Trautmann D,Fischer A,Kühl AA,Loddenkemper C,Batra A,Siegmund B,Krell HW,Bereswill S,Liesenfeld O

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Immunohistochemistry

Thu Sep 01 00:00:00 EDT 2011

DNA alkylating therapy induces tumor regression through an HMGB1-mediated activation of innate immunity.

Journal of immunology (Baltimore, Md. : 1950)

Guerriero JL,Ditsworth D,Catanzaro JM,Sabino G,Furie MB,Kew RR,Crawford HC,Zong WX

Published figure using F4/80 monoclonal antibody (Product # 67-4801-82) in Flow Cytometry

Tue Mar 15 00:00:00 EDT 2011

Bioinformatics

Protein Aliases: Adhesion G protein-coupled receptor E1; Cell surface glycoprotein F4/80; EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; lymphocyte antigen 71

Gene Aliases: Adgre1; DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480; Ly71; TM7LN3

UniProt ID: (Mouse) Q61549

Entrez Gene ID: (Mouse) 13733

Molecular Function: G-protein coupled receptor