Sequence of this protein is as follows: PGAPLPTFCW EQIRAHDQPG DKWLVIERRV YDISRWAQRH PGGSRLIGHH GAEDATDAFR AFHQDLNFVR KFLQPLLIGE LAPEEPSQDG PLNAQLVE
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.
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Protein Aliases: cytochrome b5-related protein; Delta(13) desaturase; Delta(13) fatty acid desaturase; delta-9 fatty acid desaturase; delta-9-desaturase; Fatty acid desaturase 3; linoleoyl-CoA desaturase (delta-9-desaturase)-like 3
Gene Aliases: CYB5RP; FADS3; LLCDL3
UniProt ID: (Human) Q9Y5Q0
Entrez Gene ID: (Human) 3995