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Members of the F-box protein family, such as FBXL22, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
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Protein Aliases: F-box and leucine-rich protein 22; F-box and leucine-rich repeat protein 22; F-box/LRR-repeat protein 22
Gene Aliases: 1110004B15Rik; Fbl22; FBXL22
UniProt ID: (Human) Q6P050, (Mouse) Q8C7B6
Entrez Gene ID: (Human) 283807, (Mouse) 74165
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