F-box proteins, critical components of the conserved ubiquitin-protein ligase complex SCF (Skp1/Cdc53-Cullin1/F-box), recruit substrates for ubiquitination and consequent degradation through their specific protein-protein interaction domains. Novel human F-box proteins named FBG1, FBG2, FBG3, FBG4 and FBG5 constitute a subfamily of mammalian F-box proteins. FBG genes are expressed in a limited number of human tissues including kidney, liver, brain and muscle tissues.
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Protein Aliases: Early mitotic inhibitor 1; F-box only protein 5; F-box protein Fbx5
Gene Aliases: EMI1; FBX5; Fbxo31; FBXO5
UniProt ID: (Human) Q9UKT4
Entrez Gene ID: (Human) 26271