|Tested species reactivity||Human|
|Published species reactivity||Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 6 and 312 of Human FBXW11|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
PA5-29878 targets FBXW11 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29878 immunogen is recombinant fragment corresponding to a region within amino acids 6 and 312 of Human FBXW11.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing.
PA5-29878 was used in western blot to study regulation of necrotic cell death induced by transcriptional repression through impaired RNA splicing by the hnRNP-Htt axis
|Mao Y,Tamura T,Yuki Y,Abe D,Tamada Y,Imoto S,Tanaka H,Homma H,Tagawa K,Miyano S,Okazawa H||Cell death and disease (7:null)||2016|