The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/multivesicular bodies (MVB) transport intermediates from early endosomes.
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Protein Aliases: 5 bisphosphate 5 phosphatase; 5-bisphosphate 5-phosphatase; Fig4; FIG4 homolog, SAC domain containing lipid phosphatase; FIG4 homolog, SAC1 domain containing lipid phosphatase; FIG4 homolog, SAC1 lipid phosphatase domain containing; KIAA0274; Phosphatidylinositol 3; Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; Polyphosphoinositide phosphatase; SAC domain containing protein 3; Sac domain-containing inositol phosphatase 3; SAC domain-containing protein 3; SAC3
Gene Aliases: A530089I17Rik; AI326867; ALS11; BTOP; CMT4J; dJ249I4.1; FIG4; KIAA0274; RGD1311375; SAC3; YVS