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Product Details
H00114793-M01J
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
2B4
Immunogen
FMNL2 (AAH36492, 1 a.a. approximately 178 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MDLTKREYTM HDHNTLLKEF ILNNEGKLKK LQDDAKIAQD AFDDVVKYFG ENPKTTPPSV FFPVFVRFVK AYKQAEEENE LRKKQEQALM EKLLEQEALM EQQDPKSPSH KSKRQQQELI AELRRRQVKD NRHVYEGKDG AIEDIITALK KNNITKFPNV HSRVRISSST PVVEDTQS
Target Information
Formin-like protein 2 is a cytoplasmic phosphoprotein belonging to the formin homology domain containing protein family and has a DAD (diaphanous autoregulatory domain), FH2 (formin homology 2) domain, and GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. The exact function of FMNL2 is yet to be known but reports suggest that it may have a role in the Wnt signaling pathway. Formin-related proteins are also known to play an important role in morphogenesis, cytokinesis and cell polarity. Several alternatively spliced transcript variants have been described but their full-length nature is not yet determined. It is also known to be associated with a diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblastoma. FMNL2 might be implicated in polarity control, invasion, migration or metastasis through actin filament nucleation and may be regulated by Rho family GTPase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: formin homology 2 domain containing 2; Formin homology 2 domain-containing protein 2; formin-like 2; Formin-like protein 2
Gene Aliases: FHOD2; FMNL2; KIAA1902
UniProt ID: (Human) Q96PY5
Entrez Gene ID: (Human) 114793
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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