MA1-5771 detects FMR1 in drosophila samples (does not cross react with human).
MA1-5771 has been successfully used in Western blot, immunoprecipitation, immunofluorescence and ELISA procedures.
MA15771 detects a band of approximately 85 kDa.
The MA1-5771 immunogen is His-dFMR1 (amino-terminal 580a.a.).
Store product at 4°C for up to one month, and -20°C for up to one year.
FMR1 binds RNA and is associated with polysomes. The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure. Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cg 6203 gene product from transcript cg6203-rc; CG6203-PA; CG6203-PB; CG6203-PC; CG6203-PD; CG6203-PE; CG6203-PF; CG6203-PG; CG6203-PH; CG6203-PI; CG6203-PJ; CG6203-PK; dFMR; dFMR1; drosophila fragile X mental retardation protein; Fmr1-PA; Fmr1-PB; Fmr1-PC; Fmr1-PD; Fmr1-PE; Fmr1-PF; Fmr1-PG; Fmr1-PH; Fmr1-PI; Fmr1-PJ; Fmr1-PK; fragile X; fragile X mental retardation; fragile X mental retardation 1; fragile X mental retardation gene; fragile X mental retardation protein; fragile X mental retardation protein 1; fragile X mental retardation related 1; Fragile X mental retardation syndrome-related protein 1; fragile X protein; fragile x related; fragile X related protein; fragile X retardation 1 protein; fragile X-related; fragile-X; Fragile-X mental retardation 1; Fragile-X mental retardation protein; Fragile-X-related; FXR; MGC87458; Synaptic functional regulator FMR1
Gene Aliases: AT24755; BcDNA:GM08679; CG6203; dFMR; DFmr1; DFMRP; dFXR; dFXR1; dFXRP; Dmel\CG6203; Dmel_CG6203; dmfr1; EP(3)3517; FMR; FMR1; FMRP; FXR
UniProt ID: (Fruit fly) Q8T0M0
Entrez Gene ID: (Fruit fly) 37528
Molecular Function: translation factor