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Proteintech
FOXC2 Monoclonal Antibody (3E3E1)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
68384-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig,
Rat
Published species
Human,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3E3E1
Immunogen
FOXC2 fusion protein Ag19378
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: KEAEKKVVIK SEAASPALPV ITKVETLSPE SALQGSPRSA ASTPAGSPDG SLPEHHAAAP NGLPGFSVEN IMTLRTSPPG GELSPGAGRA GLVVPPLALP YAAAPPAAYG QPCAQGLEAG AAGGYQCSMR AMSLYTGAER PAHMCVPPAL DEALSDHPSG PTSPLSALNL AAGQEGALAA TGHHHQHHGH HHPQAPPPPP APQPQPTPQP GAAAAQAASW YLNHSGDLNH LPGHTFAAQQ QTFPNVREMF NSHRLGIENS TLGESQVSGN ASCQLPYRST PPLYRHAAPY SYDCTKY
Target Information
Forkhead box protein C2 (FOXC2) is a transciptional activator and is characterized by a distinct DNA-binding forkhead domain. FOXC2 may be involved in the formation of special mesenchymal tissues. Mutations affecting the gene can cause lymphedema-distichiasis (LYD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BF-3; brain factor 3; forkhead box C2 (MFH-1, mesenchyme forkhead 1); forkhead, Drosophila, homolog-like 14; forkhead-related protein FKHL14; HFH-BF-3; mesenchyme fork head protein 1; mesenchyme forkhead 1; MFH-1,mesenchyme forkhead 1; transcription factor FKH-14
Gene Aliases: Fkh14; FKHL14; Hfhbf3; LD; MFH-1; MFH1
UniProt ID: (Human) Q99958, (Rat) Q63246
Entrez Gene ID: (Pig) 100526107, (Human) 2303, (Rat) 171356
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
chromatin DNA binding
identical protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
somitogenesis
lymphangiogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
mesoderm development
heart development
insulin receptor signaling pathway
anatomical structure morphogenesis
response to hormone
positive regulation of endothelial cell migration
cell differentiation
positive regulation of cell adhesion mediated by integrin
positive regulation of vascular wound healing
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of cold-induced thermogenesis
skeletal system development
ossification
blood vessel development
patterning of blood vessels
metanephros development
ureteric bud development
kidney development
lymph vessel development
blood vessel remodeling
heart morphogenesis
Notch signaling pathway
cell proliferation
neural crest cell development
collagen fibril organization
embryonic heart tube development
camera-type eye development
regulation of organ growth
vascular endothelial growth factor receptor signaling pathway
paraxial mesoderm formation
paraxial mesodermal cell fate commitment
embryonic cranial skeleton morphogenesis
embryonic viscerocranium morphogenesis
embryonic skeletal system morphogenesis
artery morphogenesis
ventricular cardiac muscle tissue morphogenesis
cardiac muscle cell proliferation
glomerular endothelium development
glomerular visceral epithelial cell differentiation
glomerular mesangial cell development
regulation of blood vessel diameter
negative regulation of apoptotic process involved in outflow tract morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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