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Product Details
H00002303-M12
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4A5
Immunogen
FOXC2 (NP_005242, 156 a.a. approximately 256 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: FENGSFLRRR RRFKKKDVSK EKEERAHLKE PPPAASKGAP ATPHLADAPK EAEKKVVIKS EAASPALPVI TKVETLSPES ALQGSPRSAA STPAGSPDGS L
Target Information
Forkhead box protein C2 (FOXC2) is a transciptional activator and is characterized by a distinct DNA-binding forkhead domain. FOXC2 may be involved in the formation of special mesenchymal tissues. Mutations affecting the gene can cause lymphedema-distichiasis (LYD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: forkhead box C2 (MFH-1, mesenchyme forkhead 1); Forkhead box protein C2; forkhead, Drosophila, homolog-like 14; Forkhead-related protein FKHL14; Mesenchyme fork head protein 1; mesenchyme forkhead 1; MFH-1 protein; MFH-1,mesenchyme forkhead 1; Transcription factor FKH-14
Gene Aliases: FKHL14; FOXC2; LD; MFH-1; MFH1
UniProt ID: (Human) Q99958
Entrez Gene ID: (Human) 2303
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
chromatin DNA binding
identical protein binding
sequence-specific DNA binding
transcription regulatory region DNA binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
ossification
patterning of blood vessels
metanephros development
ureteric bud development
somitogenesis
lymphangiogenesis
blood vessel remodeling
transcription from RNA polymerase II promoter
Notch signaling pathway
mesoderm development
heart development
insulin receptor signaling pathway
response to hormone
positive regulation of endothelial cell migration
neural crest cell development
collagen fibril organization
positive regulation of cell adhesion mediated by integrin
embryonic heart tube development
positive regulation of vascular wound healing
camera-type eye development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of organ growth
vascular endothelial growth factor receptor signaling pathway
paraxial mesodermal cell fate commitment
embryonic viscerocranium morphogenesis
artery morphogenesis
regulation of blood vessel size
ventricular cardiac muscle tissue morphogenesis
cardiac muscle cell proliferation
glomerular endothelium development
glomerular visceral epithelial cell differentiation
glomerular mesangial cell development
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of apoptotic process involved in outflow tract morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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