A suggested positive control for immunohistochemical applications for this product is human tonsil. This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. 1mM EDTA, pH 8.0, is recommended for this purpose.
FOXP1 is an 85 kDa member of the winged helix/forkhead transcription factor family. The FOXP1 transcription factor is widely expressed in human tissues and is predominantly localized to the nucleus. However, the level of expression does vary between cells and between different tissues. The expression of FOXP1 is reported to be abnormal in a ranger of solid tumours. Studies suggest that FOXP1 functions a a transcription repressor.
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Protein Aliases: 12CC4; FLJ23741; fork head-related protein like B; Forkhead box protein P1; Forkhead-related transcription factor 1; glutamine-rich factor 1; hFKH1B; HSPC215; Mac-1-regulated forkhead; MFH; MGC12942; MGC88572; MGC99551; QRF1
Gene Aliases: 12CC4; 3110052D19Rik; 4932443N09Rik; AI461938; AW494214; FOXP1; hFKH1B; HSPC215; MFH; QRF1