Product References
Preclinical assessment of antigen-specific chimeric antigen receptor regulatory T cells for use in solid organ transplantation.
Gene therapy
Proics E,David M,Mojibian M,Speck M,Lounnas-Mourey N,Govehovitch A,Baghdadi W,Desnouveaux J,Bastian H,Freschi L,Privat G,Pouzet C,Grossi M,Heimendinger P,Abel T,Fenard D,Levings MK,Meyer F,Dumont C
12-4777-42 was used in Flow cytometry/Cell sorting to report the preclinical characterization of Tregs (TR101) transduced with a human leukocyte antigen (HLA)-A*02 CAR lentiviral vector (TX200) designated to induce immunosuppression of allograft-specific effector T cells in HLA-A*02-negative recipients of HLA-A*02-positive transplants.
Sat Apr 01 00:00:00 EDT 2023
Tumor-associated tissue eosinophilia promotes angiogenesis and metastasis in head and neck squamous cell carcinoma.
Neoplasia (New York, N.Y.)
Lee TL,Chen TH,Kuo YJ,Lan HY,Yang MH,Chu PY
12-4777-42 was used in Luminex to investigate how tumor-associated tissue eosinophilia (TATE) can influence tumor behavior and tumor microenvironment in head and neck squamous cell carcinoma.
Sun Jan 01 00:00:00 EST 2023
Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months.
Xenotransplantation
Mohiuddin MM,Goerlich CE,Singh AK,Zhang T,Tatarov I,Lewis B,Sentz F,Hershfeld A,Braileanu G,Odonkor P,Strauss E,Williams B,Burke A,Hittman J,Bhutta A,Tabatabai A,Gupta A,Vaught T,Sorrells L,Kuravi K,Dandro A,Eyestone W,Kaczorowski DJ,Ayares D,Griffith BP
12-4777-42 was used in Flow cytometry/Cell sorting to demonstrate that selective "multi-gene" modifications improve cardiac xenograft survival significantly and may be foundational for paving the way to bridge transplantation in humans.
Sun May 01 00:00:00 EDT 2022
Aberrant newborn T cell and microbiota developmental trajectories predict respiratory compromise during infancy.
iScience
McDavid A,Laniewski N,Grier A,Gill AL,Kessler HA,Huyck H,Carbonell E,Holden-Wiltse J,Bandyopadhyay S,Carnahan J,Dylag AM,Topham DJ,Falsey AR,Caserta MT,Pryhuber GS,Gill SR,Scheible KM
12-4777-42 was used in Flow Cytometry to conclude that early exposures predict the postnatal immune-microbiota axis trajectory, placing infants at later risk for respiratory morbidity in early childhood.
Fri Apr 15 00:00:00 EDT 2022
Role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice.
Journal of autoimmunity
Khosravi-Maharlooei M,Li H,Hoelzl M,Zhao G,Ruiz A,Misra A,Li Y,Teteloshvili N,Nauman G,Danzl N,Ding X,Pinker EY,Obradovic A,Yang YG,Iuga A,Creusot RJ,Winchester R,Sykes M
12-4777-42 was used in Flow cytometry/Cell sorting to evaluate the role of the thymus in development of multi-organ autoimmunity in human immune system (HIS) mice.
Sat May 01 00:00:00 EDT 2021
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).
European journal of immunology
Cossarizza A,Chang HD,Radbruch A,Abrignani S,Addo R,Akdis M,Andrä I,Andreata F,Annunziato F,Arranz E,Bacher P,Bari S,Barnaba V,Barros-Martins J,Baumjohann D,Beccaria CG,Bernardo D,Boardman DA,Borger J,Böttcher C,Brockmann L,Burns M,Busch DH,Cameron G,Cammarata I,Cassotta A,Chang Y,Chirdo FG,Christakou E,Čičin-Šain L,Cook L,Corbett AJ,Cornelis R,Cosmi L,Davey MS,De Biasi S,De Simone G,Del Zotto G,Delacher M,Di Rosa F,Di Santo J,Diefenbach A,Dong J,Dörner T,Dress RJ,Dutertre CA,Eckle SBG,Eede P,Evrard M,Falk CS,Feuerer M,Fillatreau S,Fiz-Lopez A,Follo M,Foulds GA,Fröbel J,Gagliani N,Galletti G,Gangaev A,Garbi N,Garrote JA,Geginat J,Gherardin NA,Gibellini L,Ginhoux F,Godfrey DI,Gruarin P,Haftmann C,Hansmann L,Harpur CM,Hayday AC,Heine G,Hernández DC,Herrmann M,Hoelsken O,Huang Q,Huber S,Huber JE,Huehn J,Hundemer M,Hwang WYK,Iannacone M,Ivison SM,Jäck HM,Jani PK,Keller B,Kessler N,Ketelaars S,Knop L,Knopf J,Koay HF,Kobow K,Kriegsmann K,Kristyanto H,Krueger A,Kuehne JF,Kunze-Schumacher H,Kvistborg P,Kwok I,Latorre D,Lenz D,Levings MK,Lino AC,Liotta F,Long HM,Lugli E,MacDonald KN,Maggi L,Maini MK,Mair F,Manta C,Manz RA,Mashreghi MF,Mazzoni A,McCluskey J,Mei HE,Melchers F,Melzer S,Mielenz D,Monin L,Moretta L,Multhoff G,Muñoz LE,Muñoz-Ruiz M,Muscate F,Natalini A,Neumann K,Ng LG,Niedobitek A,Niemz J,Almeida LN,Notarbartolo S,Ostendorf L,Pallett LJ,Patel AA,Percin GI,Peruzzi G,Pinti M,Pockley AG,Pracht K,Prinz I,Pujol-Autonell I,Pulvirenti N,Quatrini L,Quinn KM,Radbruch H,Rhys H,Rodrigo MB,Romagnani C,Saggau C,Sakaguchi S,Sallusto F,Sanderink L,Sandrock I,Schauer C,Scheffold A,Scherer HU,Schiemann M,Schildberg FA,Schober K,Schoen J,Schuh W,Schüler T,Schulz AR,Schulz S,Schulze J,Simonetti S,Singh J,Sitnik KM,Stark R,Starossom S,Stehle C,Szelinski F,Tan L,Tarnok A,Tornack J,Tree TIM,van Beek JJP,van de Veen W,van Gisbergen K,Vasco C,Verheyden NA,von Borstel A,Ward-Hartstonge KA,Warnatz K,Waskow C,Wiedemann A,Wilharm A,Wing J,Wirz O,Wittner J,Yang JHM,Yang J
12-4777-42 was used in Flow cytometry/Cell sorting to provide the key aspects to consider when performing flow cytometry experiments.
Wed Dec 01 00:00:00 EST 2021
Immunological status of peripheral blood is associated with prognosis in patients with bone and soft-tissue sarcoma.
Oncology letters
Kim Y,Kobayashi E,Suehara Y,Ito A,Kubota D,Tanzawa Y,Endo M,Nakatani F,Nakatsura T,Kawai A,Kaneko K,Kitano S
12-4777 was used in Flow cytometry/Cell sorting to suggest that the immune status of peripheral blood was associated with the prognosis in patients with sarcoma, as previously reported in patients with other cancer types.
Mon Mar 01 00:00:00 EST 2021
Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes.
Cell reports
Sano T,Kageyama T,Fang V,Kedmi R,Martinez CS,Talbot J,Chen A,Cabrera I,Gorshko O,Kurakake R,Yang Y,Ng C,Schwab SR,Littman DR
12-4777-42 was used in Flow Cytometry to show that intestine-draining mesenteric lymph nodes (MLNs), not intestine proper, are the dominant site of SFB-induced intestinal Th17 cell differentiation.
Tue Aug 24 00:00:00 EDT 2021
In-Depth Immune-Oncology Studies of the Tumor Microenvironment in a Humanized Melanoma Mouse Model.
International journal of molecular sciences
Schupp J,Christians A,Zimmer N,Gleue L,Jonuleit H,Helm M,Tuettenberg A
12-4777 was used in Flow cytometry/Cell sorting to compare the multiplex method Chipcytometry to flow cytometry and classical IHCP using DAB and hematoxylin.
Wed Jan 20 00:00:00 EST 2021
Adiponectin/AdipoR1 Axis Promotes IL-10 Release by Human Regulatory T Cells.
Frontiers in immunology
Ramos-Ramírez P,Malmhäll C,Tliba O,Rådinger M,Bossios A
12-4777-42 was used in Flow Cytometry to suggest that adiponectin/AdipoR1 axis promotes IL-10 release by Tregs, mainly in Helios- Tregs, and the effect was amplified by T2 inflammation in Helios+ Tregs.
Tue Oct 26 00:00:00 EDT 2021
Changes in expression of PD-L1 on peripheral T cells in patients with melanoma and lung cancer treated with PD-1 inhibitors.
Scientific reports
Dart SJ,Cook AM,Millward MJ,McDonnell AM,Chin WL,Hakeem MU,Meniawy TM,Bowyer SE
12-4777-42 was used in Flow Cytometry to identify patients before or early in treatment who would best respond to PD-1 inhibitors.
Wed Jul 28 00:00:00 EDT 2021
Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism.
Cell
Duscha A,Gisevius B,Hirschberg S,Yissachar N,Stangl GI,Dawin E,Bader V,Haase S,Kaisler J,David C,Schneider R,Troisi R,Zent D,Hegelmaier T,Dokalis N,Gerstein S,Del Mare-Roumani S,Amidror S,Staszewski O,Poschmann G,Stühler K,Hirche F,Balogh A,Kempa S,Träger P,Zaiss MM,Holm JB,Massa MG,Nielsen HB,Faissner A,Lukas C,Gatermann SG,Scholz M,Przuntek H,Prinz M,Forslund SK,Winklhofer KF,Müller DN,Linker RA,Gold R,Haghikia A
12-4777 was used in Flow cytometry/Cell sorting to investigate propionic acid (PA) in multiple sclerosis (MS), an autoimmune and neurodegenerative disease.
Thu Mar 19 00:00:00 EDT 2020
Accumulation of TNFR2-expressing regulatory T cells in malignant pleural effusion of lung cancer patients is associated with poor prognosis.
Annals of translational medicine
Ye LL,Peng WB,Niu YR,Xiang X,Wei XS,Wang ZH,Wang X,Zhang SY,Chen X,Zhou Q
12-4777 was used in Flow cytometry/Cell sorting to investigate associations between TNFR2+Tregs frequencies present in malignant pleural effusion and the clinical and laboratorial characteristics of patients with lung cancer.
Tue Dec 01 00:00:00 EST 2020
The anti-CXCL4 antibody depletes CD4(+)CD25(+)FOXP3(+) regulatory T cells in CD4+ T cells from chronic osteomyelitis patients by the STAT5 pathway.
Annals of palliative medicine
Huang K,Ge S
12-4777 was used in Flow cytometry/Cell sorting to investigate the effect of CXCL4, a member of chemokine family, on Tregs, and the underlying mechanisms.
Tue Sep 01 00:00:00 EDT 2020
Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis.
Cell reports
Ko JH,Kim HJ,Jeong HJ,Lee HJ,Oh JY
12-4777-42 was used in Flow Cytometry to demonstrate the role of mesenchymal stem and stromal cell and macrophage cross-talk in post-injury tissue homeostasis in mice.
Tue Mar 17 00:00:00 EDT 2020
Subclinical Cytomegalovirus DNA Is Associated with CD4 T Cell Activation and Impaired CD8 T Cell CD107a Expression in People Living with HIV despite Early Antiretroviral Therapy.
Journal of virology
Christensen-Quick A,Massanella M,Frick A,Rawlings SA,Spina C,Vargas-Meneses M,Schrier R,Nakazawa M,Anderson C,Gianella S
12-4777 was used in Flow cytometry/Cell sorting to find that, when CMV was detectable, CD4+ T cell activation was higher, and CD8+ T cell degranulation was lower.
Mon Jul 01 00:00:00 EDT 2019
Stability and inhibitory function of Treg cells under inflammatory conditions in vitro.
Experimental and therapeutic medicine
Guo H,Xun L,Zhang R,Hu F,Luan J,Lao K,Wang X,Gou X
12-4777 was used in Flow cytometry/Cell sorting to detect Treg cell function under simulated inflammatory conditions to provide a foundation for Treg cell-based immunotherapy.
Tue Oct 01 00:00:00 EDT 2019
Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation.
Nature communications
Esfahani K,Al-Aubodah TA,Thebault P,Lapointe R,Hudson M,Johnson NA,Baran D,Bhulaiga N,Takano T,Cailhier JF,Piccirillo CA,Miller WH
12-4777-42 was used in Flow Cytometry to indicate that sirolimus has the potential to uncouple anti-PD-1 therapy toxicity and efficacy.
Thu Oct 17 00:00:00 EDT 2019
Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells.
JCI insight
Dawson NA,Lamarche C,Hoeppli RE,Bergqvist P,Fung VC,McIver E,Huang Q,Gillies J,Speck M,Orban PC,Bush JW,Mojibian M,Levings MK
12-4777 was used in Flow cytometry/Cell sorting to characterise and test alloantigen-specific chimeric antigen receptors in regulatory T cells.
Thu Mar 21 00:00:00 EDT 2019
Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression.
Cell
Han Y,Liu Q,Hou J,Gu Y,Zhang Y,Chen Z,Fan J,Zhou W,Qiu S,Zhang Y,Dong T,Li N,Jiang Z,Zhu H,Zhang Q,Ma Y,Zhang L,Wang Q,Yu Y,Li N,Cao X
12-4777 was used in Flow cytometry/Cell sorting to report one population of tumor-inducible, erythroblast-like cells (Ter-cells) deriving from megakaryocyte-erythroid progenitor cells with a unique Ter-119+CD45-CD71+ phenotype.
Thu Apr 19 00:00:00 EDT 2018
Cycling CD4+ T cells in HIV-infected immune nonresponders have mitochondrial dysfunction.
The Journal of clinical investigation
Younes SA,Talla A,Pereira Ribeiro S,Saidakova EV,Korolevskaya LB,Shmagel KV,Shive CL,Freeman ML,Panigrahi S,Zweig S,Balderas R,Margolis L,Douek DC,Anthony DD,Pandiyan P,Cameron M,Sieg SF,Calabrese LH,Rodriguez B,Lederman MM
12-4777 was used in Flow cytometry/Cell sorting to demonstrate that cells with the phenotype and transcriptional profile of regulatory T cells are enriched among cycling cells in health and in HIV infection.
Thu Nov 01 00:00:00 EDT 2018
Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection.
Hepatology (Baltimore, Md.)
Cobb DA,Kim OK,Golden-Mason L,Rosen HR,Hahn YS
12-4777 was used in Flow cytometry/Cell sorting to examine the accumulation of Tfr cells in the liver compartment during chronic HCV infection and defined the cellular and molecular mechanisms underlying their expansion.
Mon Jan 01 00:00:00 EST 2018
Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells.
PLoS pathogens
Tran TTP,Eichholz K,Amelio P,Moyer C,Nemerow GR,Perreau M,Mennechet FJD,Kremer EJ
12-4777 was used in Flow cytometry/Cell sorting to identify a mechanism by which an antiviral humoural response could, counterintuitively, favour virus persistence.
Wed Aug 01 00:00:00 EDT 2018
Enhanced IL-6/phosphorylated STAT3 signaling is related to the imbalance of circulating T follicular helper/T follicular regulatory cells in patients with rheumatoid arthritis.
Arthritis research & therapy
Niu Q,Huang ZC,Wu XJ,Jin YX,An YF,Li YM,Xu H,Yang B,Wang LL
12-4777 was used in Flow cytometry/Cell sorting to demonstrate that enhanced IL-6/pSTAT3 signalling may contribute to promotion of Tfh cells, consequently skewing the ratio of Tfh to Tfr cells, which may be crucial for disease progression in rheumatoid arthritis.
Wed Aug 29 00:00:00 EDT 2018
Cytokine-induced alterations of BAMBI mediate the reciprocal regulation of human Th17/Treg cells in response to cigarette smoke extract.
International journal of molecular medicine
Liu HJ,Chen G,Chen L,Zhou M,Xiong XZ,Meng ZJ,Sun SW,Tao XN
12-4777 was used in Flow cytometry/Cell sorting to characterise BMP and activin membrane-bound inhibitor expression in human CD4+ cells, as well as immune imbalance during activation and cigarette smoke exposure.
Sat Dec 01 00:00:00 EST 2018
Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses.
JCI insight
Watanabe K,Luo Y,Da T,Guedan S,Ruella M,Scholler J,Keith B,Young RM,Engels B,Sorsa S,Siurala M,Havunen R,Tähtinen S,Hemminki A,June CH
12-4777 was used in Flow cytometry/Cell sorting to investigate whether combined mesothelin-redirected chimeric antigen receptor T cell therapy with an oncolytic adenovirus expressing TNF-α and IL-2 would improve anti-tumour efficacy.
Thu Apr 05 00:00:00 EDT 2018
Early expansion of donor-specific Tregs in tolerant kidney transplant recipients.
JCI insight
Savage TM,Shonts BA,Obradovic A,Dewolf S,Lau S,Zuber J,Simpson MT,Berglund E,Fu J,Yang S,Ho SH,Tang Q,Turka LA,Shen Y,Sykes M
12-4777 was used in Flow cytometry/Cell sorting to optimise a method for identifying the donor-specific regulatory T cell (Treg) repertoire and interrogate the fate of donor-specific Tregs following combined kidney and bone marrow transplantation.
Thu Nov 15 00:00:00 EST 2018
FoxP3 isoforms and PD-1 expression by T regulatory cells in multiple sclerosis.
Scientific reports
Sambucci M,Gargano F,De Rosa V,De Bardi M,Picozza M,Placido R,Ruggieri S,Capone A,Gasperini C,Matarese G,Battistini L,Borsellino G
12-4777 was used in Flow cytometry/Cell sorting to propose a strategy to identify potentially functional and suppressive Treg cells in an autoimmune disease like multiple sclerosis.
Tue Feb 27 00:00:00 EST 2018
Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8+ T cells in the tumor microenvironment.
Journal for immunotherapy of cancer
Tada Y,Togashi Y,Kotani D,Kuwata T,Sato E,Kawazoe A,Doi T,Wada H,Nishikawa H,Shitara K
12-4777 was used in Flow cytometry/Cell sorting to study the effects of ramucirumab on the tumour microenvironmental immune status in human cancers.
Thu Oct 11 00:00:00 EDT 2018
ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic Cells.
Frontiers in immunology
Lecciso M,Ocadlikova D,Sangaletti S,Trabanelli S,De Marchi E,Orioli E,Pegoraro A,Portararo P,Jandus C,Bontadini A,Redavid A,Salvestrini V,Romero P,Colombo MP,Di Virgilio F,Cavo M,Adinolfi E,Curti A
12-4777 was used in Flow cytometry/Cell sorting to study the effect of ATP release in acute myeloid lymphoma on the generation of an immune suppressive microenvironment.
Thu Mar 31 00:00:00 EDT 2022
Immune Modifications in Fetal Membranes Overlying the Cervix Precede Parturition in Humans.
Journal of immunology (Baltimore, Md. : 1950)
Marcellin L,Schmitz T,Messaoudene M,Chader D,Parizot C,Jacques S,Delaire J,Gogusev J,Schmitt A,Lesaffre C,Breuiller-Fouché M,Caignard A,Vaiman D,Goffinet F,Cabrol D,Gorochov G,Méhats C
12-4777 was used in Flow cytometry/Cell sorting to demonstrate a change in gene expression and immune modifications in the zone of altered morphology (ZAM) of fetal membranes that occur at the onset of parturition.
Wed Feb 01 00:00:00 EST 2017
Tadalafil has biologic activity in human melanoma. Results of a pilot trial with Tadalafil in patients with metastatic Melanoma (TaMe).
Oncoimmunology
Hassel JC,Jiang H,Bender C,Winkler J,Sevko A,Shevchenko I,Halama N,Dimitrakopoulou-Strauss A,Haefeli WE,Jäger D,Enk A,Utikal J,Umansky V
12-4777 was used in Flow cytometry/Cell sorting to evaluate biologic effects, safety and efficacy of palliative treatment with the PDE-5 inhibitor tadalafil in metastatic melanoma patients.
Fri Mar 11 00:00:00 EST 2022
Oroxylin A inhibits the generation of Tregs in non-small cell lung cancer.
Oncotarget
Shen L,Zhang LL,Li H,Liu X,Yu XX,Hu P,Hui H,Guo QL,Zhang S
12-4777 was used in Flow cytometry/Cell sorting to demonstrate that oroxylin A inhibits Treg generation in lung cancer by inhibiting TGF-β1 response and secretion via NF-κB signalling.
Tue Jul 25 00:00:00 EDT 2017
Tregitopes and impaired antigen presentation: Drivers of the immunomodulatory effects of IVIg?
Immunity, inflammation and disease
Sordé L,Spindeldreher S,Palmer E,Karle A
12-4777 was used in Flow cytometry/Cell sorting to study the potential impact of IVIg on the ability of antigen presenting cells to present peptides.
Fri Dec 01 00:00:00 EST 2017
Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues.
Nature medicine
Thome JJ,Bickham KL,Ohmura Y,Kubota M,Matsuoka N,Gordon C,Granot T,Griesemer A,Lerner H,Kato T,Farber DL
12-4777 was used in Flow cytometry/Cell sorting to elucidate how the immune system avoids excessive activation as a result of encountering diverse new antigens in early life.
Fri Jan 01 00:00:00 EST 2016
Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo.
Gut
Fischer A,Zundler S,Atreya R,Rath T,Voskens C,Hirschmann S,López-Posadas R,Watson A,Becker C,Schuler G,Neufert C,Atreya I,Neurath MF
12-4777 was used in Flow cytometry/Cell sorting to analyse the homing of effector and regulatory T-cells to the inflamed gut via α4β7 and GPR15.
Sat Oct 01 00:00:00 EDT 2016
Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo.
Gut
Fischer A,Zundler S,Atreya R,Rath T,Voskens C,Hirschmann S,López-Posadas R,Watson A,Becker C,Schuler G,Neufert C,Atreya I,Neurath MF
12-4777 was used in Flow cytometry/Cell sorting to analyse the homing of effector and regulatory T-cells to the inflamed gut via α4β7 and GPR15.
Sat Oct 01 00:00:00 EDT 2016
Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII binding in rheumatoid arthritis.
The Journal of experimental medicine
Nguyen DX,Ehrenstein MR
12-4777 was used in Flow cytometry/Cell sorting to investigate whether TNF boosts of inhibits regulatory T cells (T reg cells), showing that anti-TNF drives regulatory T cell expansion by promoting membrane TNF-TNF-RII binding, in rheumatoid arthritis.
Mon Jun 27 00:00:00 EDT 2016
CD3(+)CD8(+)CD28(-) T Lymphocytes in Patients with Lupus Nephritis.
Journal of immunology research
Żabińska M,Krajewska M,Kościelska-Kasprzak K,Klinger M
12-4777 was used in Flow cytometry/Cell sorting to inquire whether quantitative changes of CD3(+)CD8(+)CD28(-) T lymphocytes subpopulation are related to the clinical status of patients with lupus nephritis.
Mon Mar 06 00:00:00 EST 2017
CD4(+)CD25(+)CD127(-) and CD4(+)CD25(+)Foxp3(+) Regulatory T Cell Subsets in Mediating Autoimmune Reactivity in Systemic Lupus Erythematosus Patients.
Archivum immunologiae et therapiae experimentalis
Żabińska M,Krajewska M,Kościelska-Kasprzak K,Jakuszko K,Bartoszek D,Myszka M,Klinger M
12-4777 was used in Flow cytometry/Cell sorting to investigate whether the quantitative changes of Treg subpopulations are related to the clinical status of patients with lupus nephritis.
Sat Oct 01 00:00:00 EDT 2016
Peripheral Blood Regulatory T-Cell and Type 1 Helper T-Cell Population Decrease after Hepatic Artery Embolization.
Journal of vascular and interventional radiology : JVIR
Takaki H,Imai N,Contessa TT,Srimathveeravalli G,Covey AM,Getrajdman GI,Brown KT,Solomon SB,Erinjeri JP
12-4777 was used in Flow Cytometry to evaluate changes in T-cell populations in peripheral blood after bland hepatic artery embolisation.
Sat Oct 01 00:00:00 EDT 2016
Imbalance between subsets of CD8(+) peripheral blood T cells in patients with chronic obstructive pulmonary disease.
PeerJ
Chen L,Chen G,Zhang MQ,Xiong XZ,Liu HJ,Xin JB,Zhang JC,Wu JH,Meng ZJ,Sun SW
12-4777 was used in Flow cytometry/Cell sorting to analyse systematically, CD8(+) cytotoxic T cell subsets in chronic obstructive pulmonary disease patients.
Mon Aug 22 00:00:00 EDT 2016
Effects of transcutaneous acupoint electrical stimulation on the imbalance of Th1, Th2, Th17 and Treg cells following thoracotomy of patients with lung cancer.
Experimental and therapeutic medicine
Wu H,Wang K,Li G,Meng D,Han J,Wang G,Li YU
12-4777 was used in Flow cytometry/Cell sorting to demonstrate that transcutaneous acupoint electrical stimulation was able to partially attenuate the postoperative immune depression of patients with lung cancer.
Mon Feb 01 00:00:00 EST 2016
Inhibition of CD39 enzymatic function at the surface of tumor cells alleviates their immunosuppressive activity.
Cancer immunology research
Bastid J,Regairaz A,Bonnefoy N,Déjou C,Giustiniani J,Laheurte C,Cochaud S,Laprevotte E,Funck-Brentano E,Hemon P,Gros L,Bec N,Larroque C,Alberici G,Bensussan A,Eliaou JF
12-4777 was used in Flow cytometry/Cell sorting to address whether CD39 is expressed by tumour cells and whether CD39+ tumour cells mediate immunosuppression via the adenosine pathway.
Sun Mar 01 00:00:00 EST 2015
Restimulation After Cryopreservation and Thawing Preserves the Phenotype and Function of Expanded Baboon Regulatory T Cells.
Transplantation direct
Weiner J,Duran-Struuck R,Zitsman J,Buhler L,Sondermeijer H,McMurchy AN,Levings MK,Sykes M,Griesemer A
12-4777 was used in Flow cytometry/Cell sorting to devise an improved method of expanding and cryopreserving Treg to maximize yield, purity, and function for use in xenotransplantation.
Sun Feb 01 00:00:00 EST 2015
High numbers of differentiated effector CD4 T cells are found in patients with cancer and correlate with clinical response after neoadjuvant therapy of breast cancer.
Cancer research
Péguillet I,Milder M,Louis D,Vincent-Salomon A,Dorval T,Piperno-Neumann S,Scholl SM,Lantz O
12-4777 was used in Flow cytometry/Cell sorting to characterise a population of human differentiated effector CD4(+) T cells that is defined by low levels of the interleukin (IL)-2 and IL-7 receptors, showing that this population expands in various types of cancer and displays cytotoxic features, suggesting that they are involved in human antitumour response.
Tue Apr 15 00:00:00 EDT 2014
Porphyromonas gingivalis infection reduces regulatory T cells in infected atherosclerosis patients.
PloS one
Yang J,Wu J,Liu Y,Huang J,Lu Z,Xie L,Sun W,Ji Y
12-4777 was used in Flow cytometry/Cell sorting to indicate that P.gingivalis infection is associated with Treg dysregulation in AS and type II FimA are the predominant genotype in this process.
Mon Sep 29 00:00:00 EDT 2014
PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation.
The Journal of biological chemistry
Li Z,Lin F,Zhuo C,Deng G,Chen Z,Yin S,Gao Z,Piccioni M,Tsun A,Cai S,Zheng SG,Zhang Y,Li B
12-4777 was used in Flow cytometry/Cell sorting to investigate PIM1 as a negative regulator of FOXP3-mediated transcriptional control and therefore the immunosuppressive activity of regulatory T cells.
Fri Sep 26 00:00:00 EDT 2014
Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities.
Journal for immunotherapy of cancer
Kovacsovics-Bankowski M,Chisholm L,Vercellini J,Tucker CG,Montler R,Haley D,Newell P,Ma J,Tseng P,Wolf R,Vetto JT,Hammill C,Hansen P,Weinberg AD
12-4777 was used in Flow cytometry/Cell sorting to analyse the phenotype and function of lymphocytes collected from patients with colorectal cancer liver metastases and ovarian cancer.
Mon Dec 01 00:00:00 EST 2014
BET bromodomain inhibition suppresses TH17-mediated pathology.
The Journal of experimental medicine
Mele DA,Salmeron A,Ghosh S,Huang HR,Bryant BM,Lora JM
12-4777 was used in Flow cytometry/Cell sorting to identify BET proteins as a fundamental link between chromatin signalling and T(H)17 biology.
Mon Oct 21 00:00:00 EDT 2013
High CCR6/CCR7 expression and Foxp3+ Treg cell number are positively related to the progression of laryngeal squamous cell carcinoma.
Oncology reports
Chen B,Zhang D,Zhou J,Li Q,Zhou L,Li SM,Zhu L,Chou KY,Zhou L,Tao L,Lu LM
12-4777 was used in Flow cytometry/Cell sorting to evaluate the expression and clinical significance of CCR6, CCR7, their ligands and CD4+CD25+Foxp3+ regulatory T cells in LSCC and LNs.
Sun Sep 01 00:00:00 EDT 2013
Tissue-infiltrating lymphocytes analysis reveals large modifications of the duodenal "immunological niche" in coeliac disease after gluten-free diet.
Clinical and translational gastroenterology
Cianci R,Cammarota G,Frisullo G,Pagliari D,Ianiro G,Martini M,Frosali S,Plantone D,Damato V,Casciano F,Landolfi R,Paola Batocchi A,Pandolfi F
12-4777 was used in Flow cytometry/Cell sorting to investigate the involvement of several T cell subpopulations in the pathogenesis of Coeliac disease.
Thu Dec 13 00:00:00 EST 2012
Th17/Treg imbalance in patients with liver cystic echinococcosis.
Parasite immunology
Tuxun T,Wang JH,Lin RY,Shan JY,Tai QW,Li T,Zhang JH,Zhao JM,Wen H
12-4777-42 was used in Flow cytometry/Cell sorting to indicate that Th17/Treg functional imbalance exists in patients with chronic cystic echinococcosis, suggesting a potential role for Th17/Treg imbalance in the pathogenesis of immune evasion in echinococcosis.
Thu Nov 01 00:00:00 EDT 2012
Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases.
Gastroenterology
Hovhannisyan Z,Treatman J,Littman DR,Mayer L
12-4777 was used in Flow cytometry/Cell sorting to investigate how Th17 and Tregs interact under chronic inflammatory conditions.
Tue Mar 01 00:00:00 EST 2011
Frequency of circulating Tregs with demethylated FOXP3 intron 1 in melanoma patients receiving tumor vaccines and potentially Treg-depleting agents.
Clinical cancer research : an official journal of the American Association for Cancer Research
de Vries IJ,Castelli C,Huygens C,Jacobs JF,Stockis J,Schuler-Thurner B,Adema GJ,Punt CJ,Rivoltini L,Schuler G,Coulie PG,Lucas S
12-4777 was used in Flow cytometry/Cell sorting to investigate the impact of three medications on blood regulatory T-cells frequency in vaccinated cancer patients.
Tue Feb 15 00:00:00 EST 2011
Role of gastric epithelial cell-derived transforming growth factor beta in reduced CD4+ T cell proliferation and development of regulatory T cells during Helicobacter pylori infection.
Infection and immunity
Beswick EJ,Pinchuk IV,Earley RB,Schmitt DA,Reyes VE
12-4777 was used in Flow cytometry/Cell sorting to show how TGF-β produced by gastric epithelial cells inhibits CD4+ T cell responses during H. pylori infection, suggesting a possible mechanism of persistence.
Fri Jul 01 00:00:00 EDT 2011
Enhanced suppressive function of regulatory T cells from patients with immune-mediated diseases following successful ex vivo expansion.
Clinical immunology (Orlando, Fla.)
Cao T,Wenzel SE,Faubion WA,Harriman G,Li L
12-4777 was used in Flow cytometry/Cell sorting to demonstrate that CD4(+)CD25(+)Foxp3(+) Treg cells from patients with autoimmune and inflammatory diseases can be successfully purified, activated and expanded, suggesting possible therapeutic potential.
Wed Sep 01 00:00:00 EDT 2010
CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection.
The Journal of infectious diseases
Green AM,Mattila JT,Bigbee CL,Bongers KS,Lin PL,Flynn JL
Sun Aug 15 00:00:00 EDT 2010
The CD4(+) T-cell response of melanoma patients to a MAGE-A3 peptide vaccine involves potential regulatory T cells.
Cancer research
François V,Ottaviani S,Renkvist N,Stockis J,Schuler G,Thielemans K,Colau D,Marchand M,Boon T,Lucas S,van der Bruggen P
12-4777 was used in Immunocytochemistry to investigate the CD4+ T-cell response of melanoma patients to a MAGE-A3 peptide vaccine.
Fri May 15 00:00:00 EDT 2009
The CD4(+) T-cell response of melanoma patients to a MAGE-A3 peptide vaccine involves potential regulatory T cells.
Cancer research
François V,Ottaviani S,Renkvist N,Stockis J,Schuler G,Thielemans K,Colau D,Marchand M,Boon T,Lucas S,van der Bruggen P
12-4777 was used in Immunocytochemistry to investigate the CD4+ T-cell response of melanoma patients to a MAGE-A3 peptide vaccine.
Fri May 15 00:00:00 EDT 2009
FoxP3+ regulatory T cells suppress early stages of granuloma formation but have little impact on sarcoidosis lesions.
The American journal of pathology
Taflin C,Miyara M,Nochy D,Valeyre D,Naccache JM,Altare F,Salek-Peyron P,Badoual C,Bruneval P,Haroche J,Mathian A,Amoura Z,Hill G,Gorochov G
12-4777-42 was used in Flow cytometry to study the correlation between the presence of regulatory T cells in renal granulomas and the degree of intestinal fibrosis.
Sun Feb 01 00:00:00 EST 2009
De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid.
Journal of immunology (Baltimore, Md. : 1950)
Wang J,Huizinga TW,Toes RE
12-4777 was used in Flow cytometry/Cell sorting to investigate methods to convert T cells into Treg cells, showing that retinoic acid can be used for de novo generation of Tregs.
Tue Sep 15 00:00:00 EDT 2009
Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques.
Journal of immunology (Baltimore, Md. : 1950)
Estes JD,Gordon SN,Zeng M,Chahroudi AM,Dunham RM,Staprans SI,Reilly CS,Silvestri G,Haase AT
Thu May 15 00:00:00 EDT 2008
