Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells.
Genes & diseases
Yang L,Jing Y,Kang D,Jiang P,Li N,Zhou X,Chen Y,Westerberg LS,Liu C
53-5773-82 was used in Flow Cytometry to identify the role of USP18 in Tregs differentiation and its suppressive function.
Sat May 01 00:00:00 EDT 2021
Continued Bcl6 Expression Prevents the Transdifferentiation of Established Tfh Cells into Th1 Cells during Acute Viral Infection.
Alterauge D,Bagnoli JW,Dahlström F,Bradford BM,Mabbott NA,Buch T,Enard W,Baumjohann D
53-5773-82 was used in Flow Cytometry to evaluate the contributions of the CXCR5 receptor and Bcl6 transcription factor in maintaining T follicular helper cells and germinal centres.
Tue Oct 06 00:00:00 EDT 2020
Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy.
Wu L,Hollinshead KER,Hao Y,Au C,Kroehling L,Ng C,Lin WY,Li D,Silva HM,Shin J,Lafaille JJ,Possemato R,Pacold ME,Papagiannakopoulos T,Kimmelman AC,Satija R,Littman DR
53-5773-82 was used in Flow Cytometry to suggest that inhibiting glycolysis by targeting Gpi1 could be an effective therapeutic strategy with minimum toxicity for Th17-mediated autoimmune diseases, and, more generally, that metabolic redundancies can be exploited for selective targeting of disease processes.
Thu Aug 06 00:00:00 EDT 2020
Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells.
The Journal of clinical investigation
Khiew SH,Jain D,Chen J,Yang J,Yin D,Young JS,Dent A,Sciammas R,Alegre ML,Chong AS
53-5773 was used in Flow cytometry/Cell sorting to showed that alloreactive B cells were not deleted but rapidly lost their ability to differentiate into germinal center B cells and secrete donor-specific antibodies., by using a murine model of heart tolerance.
Wed Jul 01 00:00:00 EDT 2020
Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA.
Soni C,Perez OA,Voss WN,Pucella JN,Serpas L,Mehl J,Ching KL,Goike J,Georgiou G,Ippolito GC,Sisirak V,Reizis B
53-5773-82 was used in Flow Cytometry to establish extrafollicular B cell differentiation into short-lived AFCs as a key mechanism of anti-DNA autoreactivity and reveal a major contribution of pDCs, endosomal Toll-like receptors (TLRs), and IFN-I to this pathway.
Tue Jun 16 00:00:00 EDT 2020
Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis.
Garofalo S,Cocozza G,Porzia A,Inghilleri M,Raspa M,Scavizzi F,Aronica E,Bernardini G,Peng L,Ransohoff RM,Santoni A,Limatola C
53-5773 was used in Immunohistochemistry-immunofluorescence to study the role of NK cells in determining the onset and progression of motor neuron degeneration in Amyotrophic Lateral Sclerosis.
Tue Apr 14 00:00:00 EDT 2020
STING couples with PI3K to regulate actin reorganization during BCR activation.
Jing Y,Dai X,Yang L,Kang D,Jiang P,Li N,Cheng J,Li J,Miller H,Ren B,Gong Q,Yin W,Liu Z,Mattila PK,Ning Q,Sun J,Yu B,Liu C
53-5773 was used in Flow cytometry/Cell sorting to study the effect of STING (stimulator of interferon genes) deficiency on B cell development, differentiation, and BCR signalling.
Wed Apr 01 00:00:00 EDT 2020
Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity.
Kimura S,Nakamura Y,Kobayashi N,Shiroguchi K,Kawakami E,Mutoh M,Takahashi-Iwanaga H,Yamada T,Hisamoto M,Nakamura M,Udagawa N,Sato S,Kaisho T,Iwanaga T,Hase K
53-5773 was used in Flow cytometry/Cell sorting to identify that the balance between infectious risk and the ability to perform immunosurveillance at the mucosal surface is dependent on osteprotegerin-dependent self-regulation of M cell differentiation.
Mon Jan 13 00:00:00 EST 2020
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.
Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR
53-5773 was used in Flow cytometry/Cell sorting to suggest that serum amyloid A proteins direct a pathogenic pro-inflammatory Th17 cell differentiation program and promote Th17-mediated inflammatory diseases.
Thu Jan 09 00:00:00 EST 2020
Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming.
Simula L,Pacella I,Colamatteo A,Procaccini C,Cancila V,Bordi M,Tregnago C,Corrado M,Pigazzi M,Barnaba V,Tripodo C,Matarese G,Piconese S,Campello S
53-5773 was used in Flow cytometry/Cell sorting to describe the crucial role of the mitochondrial protein Drp1 in T cell development and regulation of lymphocyte immune-surveillance.
Tue Dec 11 00:00:00 EST 2018
Differential Roles of IL-2 Signaling in Developing versus Mature Tregs.
Fan MY,Low JS,Tanimine N,Finn KK,Priyadharshini B,Germana SK,Kaech SM,Turka LA
53-5773 was used in Flow cytometry/Cell sorting to study the differential roles of IL-2 signalling in developing versus mature regulatory T cells.
Tue Oct 30 00:00:00 EDT 2018
IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection.
Fabié A,Mai LT,Dagenais-Lussier X,Hammami A,van Grevenynghe J,Stäger S
53-5773 was used in Flow cytometry/Cell sorting to demonstrate that IRF-5 is increasingly expressed in interferon (IFN)-γ+ CD4 T cells over the course of L. donovani infection.
Tue Jul 31 00:00:00 EDT 2018
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.
Cho S,Lee HM,Yu IS,Choi YS,Huang HY,Hashemifar SS,Lin LL,Chen MC,Afanasiev ND,Khan AA,Lin SW,Rudensky AY,Crotty S,Lu LF
53-5773 was used in Flow cytometry/Cell sorting to reveal differential cell-intrinsic regulations of GC B and Tfh cells by miR-146a and miR-146b.
Mon Jul 16 00:00:00 EDT 2018
Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response.
Frontiers in cellular and infection microbiology
Ahmed N,French T,Rausch S,Kühl A,Hemminger K,Dunay IR,Steinfelder S,Hartmann S
53-5773 was used in Flow cytometry/Cell sorting to conclude a previous T. gondii infection limits a helminth-specific Th2 immune response while promoting a shift toward a Th1-type immune response.
Mon Apr 02 00:00:00 EDT 2018
Huai Qi Huang corrects the balance of Th1/Th2 and Treg/Th17 in an ovalbumin-induced asthma mouse model.
Liang P,Peng S,Zhang M,Ma Y,Zhen X,Li H
53-5773 was used in Flow cytometry/Cell sorting to determine the immunoregulatory effects of Huai Qi Huang on regulatory and helper T cell balance in ovalbumin induced asthma.
Fri Dec 22 00:00:00 EST 2017
Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells.
Hayatsu N,Miyao T,Tachibana M,Murakami R,Kimura A,Kato T,Kawakami E,Endo TA,Setoguchi R,Watarai H,Nishikawa T,Yasuda T,Yoshida H,Hori S
53-5773 was used in Flow cytometry/Cell sorting to identify BATF as a regulator of tissue regulatory T cells and suggest that sequence-specific perturbations of Foxp3-DNA interactions can influence specific facets of Treg physiology and the immunopathologies.
Tue Aug 15 00:00:00 EDT 2017
Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment.
Breast cancer research : BCR
García-Mendoza MG,Inman DR,Ponik SM,Jeffery JJ,Sheerar DS,Van Doorn RR,Keely PJ
53-5773 was used in Flow cytometry/Cell sorting to suggest that tumor progression in a collagen-dense microenvironment is mechanistically different, with pro-tumor neutrophils, compared to a non-dense microenvironment.
Wed May 11 00:00:00 EDT 2016
A Novel Transgenic Mouse Line for Tracing MicroRNA-155-5p Activity In Vivo.
Phiwpan K,Guo J,Zhang W,Hu T,Boruah BM,Zhang J,Zhou X
53-5773 was used in Flow cytometry/Cell sorting to demonstrate a novel approach for detecting miR expression in specific cell types of interest.
Tue Apr 12 00:00:00 EDT 2016
Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation.
Yang BH,Hagemann S,Mamareli P,Lauer U,Hoffmann U,Beckstette M,Föhse L,Prinz I,Pezoldt J,Suerbaum S,Sparwasser T,Hamann A,Floess S,Huehn J,Lochner M
53-5773 was used in Flow cytometry/Cell sorting to demonstrate that Foxp3(+) T cells expressing retinoic acid-related orphan receptor-γt, represent a stable regulatory T cell lineage with a highly suppressive phenotype in vivo.
Tue Mar 01 00:00:00 EST 2016
Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses.
Halim TY,Hwang YY,Scanlon ST,Zaghouani H,Garbi N,Fallon PG,McKenzie AN
53-5773 was used in Flow cytometry/Cell sorting to investigate the role of ILC2 cells in allergic inflammation, showing that they license dendritic cells to potentiate memory TH2 cell responses.
Fri Jan 01 00:00:00 EST 2016
Peak inflammation in atherosclerosis, primary biliary cirrhosis and autoimmune arthritis is counter-intuitively associated with regulatory T cell enrichment.
Garetto S,Trovato AE,Lleo A,Sala F,Martini E,Betz AG,Norata GD,Invernizzi P,Kallikourdis M
53-5773 was used in Flow cytometry/Cell sorting to investigate the dynamic between regulatory T cell mediated inflammation and immunosuppression.
Sat Aug 01 00:00:00 EDT 2015
Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis.
Kim MS,Yan J,Wu W,Zhang G,Zhang Y,Cai D
53-5773 was used in Flow cytometry/Cell sorting to investigate the role of the brain in innate immunological signals, showing rapid linkage of innate signals and adaptive immunity by the brain-fat axis.
Fri May 01 00:00:00 EDT 2015
Diverse roles for T-bet in the effector responses required for resistance to infection.
Journal of immunology (Baltimore, Md. : 1950)
Harms Pritchard G,Hall AO,Christian DA,Wagage S,Fang Q,Muallem G,John B,Glatman Zaretsky A,Dunn WG,Perrigoue J,Reiner SL,Hunter CA
53-5773 was used in Flow cytometry/Cell sorting to highlight T-bet-independent pathways to IFN-γ production and reveal a novel role for this transcription factor in coordinating the T cell responses necessary to control infection in peripheral tissues.
Sun Feb 01 00:00:00 EST 2015
Grazing dairy cows had decreased interferon-γ, tumor necrosis factor, and interleukin-17, and increased expression of interleukin-10 during the first week after calving.
Journal of dairy science
Heiser A,McCarthy A,Wedlock N,Meier S,Kay J,Walker C,Crookenden MA,Mitchell MD,Morgan S,Watkins K,Loor JJ,Roche JR
53-5773 was used in Flow cytometry/Cell sorting to highlight a characteristic expression pattern for IFNγ, tumor necrosis factor, IL-17, and IL-10 that reflects a state of reduced immunocompetence in moderate-yielding pasture-based transition cows after calving.
Sun Feb 01 00:00:00 EST 2015
Natural history of tumor growth and immune modulation in common spontaneous murine mammary tumor models.
Breast cancer research and treatment
Gad E,Rastetter L,Slota M,Koehnlein M,Treuting PM,Dang Y,Stanton S,Disis ML
53-5773 was used in Flow cytometry/Cell sorting to evaluate the relationship between growth rates of tumours in common spontaneous mammary tumor models and immune biomarkers evaluated in the tumour and blood.
Mon Dec 01 00:00:00 EST 2014
Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes.
Hypertension (Dallas, Tex. : 1979)
Amador CA,Barrientos V,Peña J,Herrada AA,González M,Valdés S,Carrasco L,Alzamora R,Figueroa F,Kalergis AM,Michea L
53-5773 was used in Flow cytometry/Cell sorting to study the adaptive immune response-induced inflammatory mechanisms contributing to fibrosis.
Tue Apr 01 00:00:00 EDT 2014
The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage.
Journal of immunology (Baltimore, Md. : 1950)
Lee PH,Puppi M,Schluns KS,Yu-Lee LY,Dong C,Lacorazza HD
53-5773 was used in Flow cytometry/Cell sorting to purified cells CD4+ T cells are inhibited from differentiating into Th17 cells by E74-like Factor 4.
Wed Jan 01 00:00:00 EST 2014
Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in mice.
Journal of virology
Durant LR,Makris S,Voorburg CM,Loebbermann J,Johansson C,Openshaw PJ
53-5773 was used in Flow cytometry/Cell sorting to provide evidence that dysregulation of normal immune responses to viral infection may contribute to severe respiratory viral disease.
Tue Oct 01 00:00:00 EDT 2013
Negative regulation of pulmonary Th17 responses by C3a anaphylatoxin during allergic inflammation in mice.
Lim H,Kim YU,Drouin SM,Mueller-Ortiz S,Yun K,Morschl E,Wetsel RA,Chung Y
53-5773 was used in Flow cytometry/Cell sorting to demonstrate that C3a signals negatively regulate antigen-specific Th17 responses during allergic lung inflammation and the Foxp3(+) regulatory T cell population.
Thu Jun 27 00:00:00 EDT 2013
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
Hall AO,Beiting DP,Tato C,John B,Oldenhove G,Lombana CG,Pritchard GH,Silver JS,Bouladoux N,Stumhofer JS,Harris TH,Grainger J,Wojno ED,Wagage S,Roos DS,Scott P,Turka LA,Cherry S,Reiner SL,Cua D,Belkaid Y,Elloso MM,Hunter CA
53-5773 was used in Flow cytometry/Cell sorting to study the promotion of distinct Treg cell populations by the cytokines IL-27 and IFN-y, and the role they play in limiting infection induced pathology.
Fri Sep 21 00:00:00 EDT 2012
Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments.
Cellular & molecular immunology
Trama AM,Holzknecht ZE,Thomas AD,Su KY,Lee SM,Foltz EE,Perkins SE,Lin SS,Parker W
53-5773 was used in Flow cytometry/Cell sorting to lend insight into the pathogenesis of post-industrial epidemics of allergy and autoimmune disease.
Thu Mar 01 00:00:00 EST 2012
CD4+ Foxp3+ regulatory T cells mediate Toxoplasma gondii-induced T-cell suppression through an IL-2-related mechanism but independently of IL-10.
European journal of immunology
Tenorio EP,Fernández J,Castellanos C,Olguín JE,Saavedra R
53-5773 was used in Flow cytometry/Cell sorting to study the role of Treg cells in Toxoplasma gondii induced suppression.
Thu Dec 01 00:00:00 EST 2011
Sensitive detection of Foxp3 expression in bovine lymphocytes by flow cytometry.
Veterinary immunology and immunopathology
Gerner W,Stadler M,Hammer SE,Klein D,Saalmüller A
Mon Nov 15 00:00:00 EST 2010
Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice.
Clinical immunology (Orlando, Fla.)
Gebe JA,Unrath KA,Falk BA,Ito K,Wen L,Daniels TL,Lernmark A,Nepom GT
53-5773 was used in Immunohistochemistry on frozen tissues to identify an age-dependent spontaneous loss of tolerance to two self-antigenic epitopes derived from putative diabetes-associated antigens in HLA specific transgenic mice.
Fri Dec 01 00:00:00 EST 2006