Identification of cell types in multiplexed in situ images by combining protein expression and spatial information using CELESTA.
Zhang W,Li I,Reticker-Flynn NE,Good Z,Chang S,Samusik N,Saumyaa S,Li Y,Zhou X,Liang R,Kong CS,Le QT,Gentles AJ,Sunwoo JB,Nolan GP,Engleman EG,Plevritis SK
12-4771-82 was used in In vivo experiments to demonstrate the power of CELESTA to facilitate identification of clinically relevant interactions.
Wed Jun 01 00:00:00 EDT 2022
Ding's herbal enema treats dextran sulfate sodium-induced colitis in mice by regulating the gut microbiota and maintaining the Treg/Th17 cell balance.
Experimental and therapeutic medicine
Tan YY,Ding Y,Zheng X,Dai GJ,Zhang SM,Yang X,Xu DC,Chen P,Zhang JM,Ma JZ,Li M,Huang SC,Liu Y,Zhang YT,Xing H,Ding K,Ding YJ
12-4771-82 was used in Flow cytometry/Cell sorting to determine the molecular mechanism of the effect of DHEP in UC treatment.
Wed Dec 01 00:00:00 EST 2021
Obesity results in adipose tissue T cell exhaustion.
Porsche CE,Delproposto JB,Geletka L,O'Rourke R,Lumeng CN
12-4771-82 was used in Flow Cytometry to assess adipose tissue T cells activation and inflammatory potential within mouse and human stromal vascular fraction.
Thu Apr 22 00:00:00 EDT 2021
Activin A Promotes Regulatory T-cell-Mediated Immunosuppression in Irradiated Breast Cancer.
Cancer immunology research
De Martino M,Daviaud C,Diamond JM,Kraynak J,Alard A,Formenti SC,Miller LD,Demaria S,Vanpouille-Box C
12-4771-82 was used in Flow Cytometry to shed light on an immune escape mechanism driven by activin A and suggest that dual targeting of activin A and TGFβ may be required to optimally unleash radiation-induced antitumor immunity against breast cancer.
Fri Jan 01 00:00:00 EST 2021
ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.
Hanson A,Elpek K,Duong E,Shallberg L,Fan M,Johnson C,Wallace M,Mabry GR,Sazinsky S,Pepper L,Shu CJ,Sathyanarayanan S,Zuerndorfer S,Simpson T,Gostissa M,Briskin M,Law D,Michaelson J,Harvey CJ
12-4771 was used in Flow cytometry/Cell sorting to describe the generation of specific, species cross-reactive, agonist antibodies to ICOS, including the humanized clinical candidate, JTX-2011 (vopratelimab).
Mon Nov 16 00:00:00 EST 2020
Bacteria-triggered tumor-specific thrombosis to enable potent photothermal immunotherapy of cancer.
Yi X,Zhou H,Chao Y,Xiong S,Zhong J,Chai Z,Yang K,Liu Z
12-4771 was used in Flow Cytometry/Cell Sorting to demonstrate that bacteria by themselves could act as a tumor-specific PTT agent to enable photoimmunotherapy cancer therapy to inhibit tumor metastasis and recurrence.
Sat Aug 01 00:00:00 EDT 2020
IFN-γ promoted exosomes from mesenchymal stem cells to attenuate colitis via miR-125a and miR-125b.
Cell death & disease
Yang R,Huang H,Cui S,Zhou Y,Zhang T,Zhou Y
12-4771-82 was used in Flow Cytometry to investigate the potential anti-inflammatory effects of bone marrow mesenchymal stem cell-derived exosomes.
Thu Jul 30 00:00:00 EDT 2020
Adipose tissue dendritic cell signals are required to maintain T cell homeostasis and obesity-induced expansion.
Molecular and cellular endocrinology
Porsche CE,Delproposto JB,Patrick E,Zamarron BF,Lumeng CN
12-4771 was used in Flow cytometry/Cell sorting to investigate the contribution of dendritic cells to adipose tissue derived chronic inflammation as professional antigen presenting cells in adipose issue.
Sun Apr 05 00:00:00 EDT 2020
Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis.
Ko JH,Kim HJ,Jeong HJ,Lee HJ,Oh JY
12-4771-82 was used in Flow Cytometry to demonstrate the role of mesenchymal stem and stromal cell and macrophage cross-talk in post-injury tissue homeostasis in mice.
Tue Mar 17 00:00:00 EDT 2020
The Combined Use of Melatonin and an Indoleamine 2,3-Dioxygenase-1 Inhibitor Enhances Vaccine-Induced Protective Cellular Immunity to HPV16-Associated Tumors.
Frontiers in immunology
Moreno ACR,Porchia BFMM,Pagni RL,Souza PDC,Pegoraro R,Rodrigues KB,Barros TB,Aps LRMM,de Araújo EF,Calich VLG,Ferreira LCS
Thu Sep 19 00:00:00 EDT 2019
Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice.
Yue W,Chen L,Yu L,Zhou B,Yin H,Ren W,Liu C,Guo L,Zhang Y,Sun L,Zhang K,Xu H,Chen Y
Thu May 02 00:00:00 EDT 2019
Bilateral Effect of the Unilateral Corneal Nerve Cut on Both Ocular Surface and Lacrimal Gland.
Investigative ophthalmology & visual science
Lee HK,Kim KW,Ryu JS,Jeong HJ,Lee SM,Kim MK
12-4771 was used in Flow cytometry/Cell sorting to demonstrate that a unilateral cut of the corneal nerve results in activation of immune cells on the ocular surface and dysregulation of lacrimal secretion bilaterally through the bidirectional neuronal signals.
Wed Jan 02 00:00:00 EST 2019
A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma.
Journal of enzyme inhibition and medicinal chemistry
Xu G,Wang T,Li Y,Huang Z,Wang X,Zheng J,Yang S,Fan Y,Xiang R
12-4771 was used in Flow cytometry/Cell sorting to discover a novel inhibitor of indoleamine 2,3-dioxygenase 1 with an increased potent activity compared with other inhibitors in clinical trials.
Sat Dec 01 00:00:00 EST 2018
Intraperitoneal neutrophils activated by KRAS-induced ovarian cancer exert antitumor effects by modulating adaptive immunity.
International journal of oncology
Yoshida M,Taguchi A,Kawana K,Ogishima J,Adachi K,Kawata A,Nakamura H,Sato M,Fujimoto A,Inoue T,Tomio K,Mori M,Nagamatsu T,Arimoto T,Koga K,Hiraike OW,Oda K,Kiyono T,Osuga Y,Fujii T
Mon Oct 01 00:00:00 EDT 2018
Loss of Gαq impairs regulatory B-cell function.
Arthritis research & therapy
He Y,Yuan X,Li Y,Zhong C,Liu Y,Qian H,Xuan J,Duan L,Shi G
12-4771 was used in Flow cytometry/Cell sorting to study the role of Gaq in the modulation of regulatory B cell function.
Fri Aug 24 00:00:00 EDT 2018
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.
Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y
12-4771 was used in Flow cytometry/Cell sorting to assess the efficacy of a personalised cancer vaccine for eliciting postsurgical tumour specific-immunity.
Wed Apr 18 00:00:00 EDT 2018
Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.
Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH
12-4771 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic advantage of using an immunomodulatory mAb to regulate lymphoid cells, which then recruit and activate myeloid cells for enhanced killing of mAb-opsonized tumors.
Mon Dec 11 00:00:00 EST 2017
Respiratory Syncytial Virus Exacerbates OVA-mediated asthma in mice through C5a-C5aR regulating CD4+T cells Immune Responses.
Hu X,Li X,Hu C,Qin L,He R,Luo L,Tang W,Feng J
12-4771 was used in Flow cytometry/Cell sorting to indicate that respiratory syncytial virus infection can increase C5a and C5aR expression in the pathogenesis of infected, asthmatic mice.
Thu Nov 09 00:00:00 EST 2017
Herpes Simplex Virus Glycoprotein D Targets a Specific Dendritic Cell Subset and Improves the Performance of Vaccines to Human Papillomavirus-Associated Tumors.
Molecular cancer therapeutics
Porchia BFMM,Moreno ACR,Ramos RN,Diniz MO,de Andrade LHTM,Rosa DS,Barbuto JAM,Boscardin SB,Ferreira LCS
Fri Sep 01 00:00:00 EDT 2017
Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation.
Marinho FV,Alves CC,de Souza SC,da Silva CM,Cassali GD,Oliveira SC,Pacifico LG,Fonseca CT
12-4771 was used in Flow cytometry/Cell sorting to analyse airway inflammation in asthmatic mice challenged with ovalbumin after intraperitoneal inoculation with Smteg.
Mon Jul 24 00:00:00 EDT 2017
Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis.
Tengvall S,Eneljung T,Jirholt P,Turesson O,Wing K,Holmdahl R,Kihlberg J,Stern A,Mårtensson IL,Henningsson L,Gustafsson K,Gjertsson I
12-4771 was used in Flow cytometry/Cell sorting to investigate induction of immunological tolerance by lentiviral based gene therapy in a mouse model of rheumatoid arthritis.
Mon Jul 17 00:00:00 EDT 2017
Virulence-Dependent Alterations in the Kinetics of Immune Cells during Pulmonary Infection by Mycobacterium tuberculosis.
Kim WS,Kim JS,Cha SB,Han SJ,Kim H,Kwon KW,Kim SJ,Eum SY,Cho SN,Shin SJ
12-4771 was used in Flow cytometry/Cell sorting to compare the bacterial burden, inflammation and kinetics of immune cells during aerogenic infection in the lung between laboratory-adapted strains (Mtb H37Rv and H37Ra) and Mtb K strain.
Mon Jun 27 00:00:00 EDT 2016
Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis.
Arthritis research & therapy
Andersson SE,Eneljung T,Tengvall S,Jirholt P,Stern A,Henningsson L,Liang B,Thorarinsdottir K,Kihlberg J,Holmdahl R,Mårtensson IL,Gustafsson K,Gjertsson I
12-4771 was used in Flow cytometry/Cell sorting to investigate how endogenous presentation of the CII-peptide on B cells is one of the key contributors to arthritis tolerance induction and maintenance.
Tue Jun 14 00:00:00 EDT 2016
Ubiquitous Over-Expression of Chromatin Remodeling Factor SRG3 Ameliorates the T Cell-Mediated Exacerbation of EAE by Modulating the Phenotypes of both Dendritic Cells and Macrophages.
Lee SW,Park HJ,Jeon SH,Lee C,Seong RH,Park SH,Hong S
12-4771 was used in Flow cytometry/Cell sorting to investigate the role of a SWI3-related gene in experimental autoimmune encephalomyelitis development.
Mon Apr 11 00:00:00 EDT 2016
Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity.
Li Y,Fang M,Zhang J,Wang J,Song Y,Shi J,Li W,Wu G,Ren J,Wang Z,Zou W,Wang L
12-4771 was used in Flow cytometry/Cell sorting to assess an alginate-hydrogel-mediated, combinatorial therapy of celecoxib and PD-1 mAb as a potential valuable regimen for treating human cancer.
Mon Feb 01 00:00:00 EST 2016
Foxp3 expression in macrophages associated with RENCA tumors in mice.
Devaud C,Yong CS,John LB,Westwood JA,Duong CP,House CM,Denoyer D,Li J,Darcy PK,Kershaw MH
12-4771 was used in Flow cytometry/Cell sorting to study how tumour-associated macrophages could express Foxp3.
Mon Nov 16 00:00:00 EST 2015
Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1.
Maneva-Radicheva L,Amatya C,Parker C,Ellefson J,Radichev I,Raghavan A,Charles ML,Williams MS,Robbins MS,Savinov AY
12-4771 was used in Flow cytometry/Cell sorting to reveal that the protein, DM199, may benefit type 1 diabetics by attenuating autoimmunity and improving beta cell health.
Wed Jun 10 00:00:00 EDT 2015
Antigen-specific gene therapy after immunisation reduces the severity of collagen-induced arthritis.
Clinical & developmental immunology
Eneljung T,Tengvall S,Jirholt P,Henningsson L,Holmdahl R,Gustafsson K,Gjertsson I
12-4771 was used in Flow cytometry/Cell sorting to show antigen-specific gene therapy is effective when administered during the inflammatory course of arthritis.
Mon Aug 04 00:00:00 EDT 2014
Low-dose 5-aza-2'-deoxycytidine pretreatment inhibits experimental autoimmune encephalomyelitis by induction of regulatory T cells.
Molecular medicine (Cambridge, Mass.)
Chan MW,Chang CB,Tung CH,Sun J,Suen JL,Wu SF
12-4771 was used in Flow cytometry/Cell sorting to investigate whether loss of P53 function contributes to persistent activation of STAT3 and modification of the pancreatic tumor stroma.
Thu Jun 26 00:00:00 EDT 2014
Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development.
The Journal of biological chemistry
Wong LY,Hatfield JK,Brown MA
12-4771 was used in Flow cytometry/Cell sorting to investigate the factors that influence the development of Th17 cells, showing that lineage gene expression is set by Ikaros.
Fri Dec 06 00:00:00 EST 2013
Killer Treg cells ameliorate inflammatory insulitis in non-obese diabetic mice through local and systemic immunomodulation.
Kaminitz A,Yolcu ES,Mizrahi K,Shirwan H,Askenasy N
12-4771 was used in Flow cytometry/Cell sorting to evaluate the capacity of naive and killer Treg cells to modulate the course of inflammatory insulitis after onset of hyperglycemia in NOD mice.
Thu Aug 01 00:00:00 EDT 2013
R-phycoerythrin-conjugated antibodies are inappropriate for intracellular staining of murine plasma cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Kim MS,Kim TS
12-4771-82 was used in Flow cytometry/Cell sorting to show that PE-conjugated antibodies are inappropriate for intracellular staining of murine plasma cells.
Wed May 01 00:00:00 EDT 2013
Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice.
Kaminitz A,Yolcu ES,Askenasy EM,Stein J,Yaniv I,Shirwan H,Askenasy N
12-4771 was used in Flow cytometry/Cell sorting to document negative regulation of effector and suppressor cells by Fas cross-linking and dissociation between sensitivity to apoptosis and proliferation in stimulated Treg.
Thu Dec 01 00:00:00 EST 2011
Chronic chemoimmunotherapy achieves cure of spontaneous murine mammary tumors via persistent blockade of posttherapy counter-regulation.
Journal of immunology (Baltimore, Md. : 1950)
Rowswell-Turner RB,Harden JL,Nair RE,Gu T,Kilinc MO,Egilmez NK
12-4771 was used in Flow cytometry/Cell sorting to demonstrate that chronic administration of cyclophosphamide in conjunction with immunotherapy sustains the cytotoxic activity of antitumor T-effector cells.
Sat Oct 15 00:00:00 EDT 2011
Memory phenotype CD4 T cells undergoing rapid, nonburst-like, cytokine-driven proliferation can be distinguished from antigen-experienced memory cells.
Younes SA,Punkosdy G,Caucheteux S,Chen T,Grossman Z,Paul WE
12-4771 was used in Flow cytometry/Cell sorting to identify and characterise two sub-populations of memory T cells.
Sat Oct 01 00:00:00 EDT 2011
Apoptosis of purified CD4+ T cell subsets is dominated by cytokine deprivation and absence of other cells in new onset diabetic NOD mice.
Kaminitz A,Askenasy EM,Yaniv I,Stein J,Askenasy N
12-4771 was used in Flow cytometry/Cell sorting to study the sensitivity of Tregs to apoptosis in diabetic NOD mice.
Fri Dec 31 00:00:00 EST 2010
Tyramide signal amplification for analysis of kinase activity by intracellular flow cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Clutter MR,Heffner GC,Krutzik PO,Sachen KL,Nolan GP
12-4771 was used in Flow cytometry/Cell sorting to optimise the tyramide signal amplification method to profile Stat1 phosphorylation in primary immune system cells.
Mon Nov 01 00:00:00 EDT 2010
Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model.
The Journal of allergy and clinical immunology
Amu S,Saunders SP,Kronenberg M,Mangan NE,Atzberger A,Fallon PG
12-4771 was used in Immunocytochemistry to identify and characterise the specific helminth-induced regulatory B-cell subpopulation, and determine the mechanism by which these regulatory B cells suppress allergic airway inflammation.
Sat May 01 00:00:00 EDT 2010