Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast growth factor receptor substrate 2; SNT-1; SNT2; Suc1-associated neurotrophic factor target 1
Gene Aliases: FRS1A; FRS2; FRS2A; FRS2alpha; SNT; SNT-1; SNT1
UniProt ID: (Human) Q8WU20
Entrez Gene ID: (Human) 10818