|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgM|
|Immunogen||Human colorectal carcinoma cell line Ls174T.|
|Contains||0.05% sodium azide|
|Storage conditions||4° C|
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3/1; 4-fucosyltransferase; alpha-(1,3/1,4)-fucosyltransferase; alpha-1; Blood group Lewis alpha-4-fucosyltransferase; CD174; FT3B; Fucosyltransferase 3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); Fucosyltransferase III; FucT-III; Galactoside 3(4)-L-fucosyltransferase; galactoside 34-L-fucosyltransferase; LE; Les; Lewis FT; Lewis Y
Gene Aliases: CD174; FT3B; FucT-III; FUT3; LE; Les
UniProt ID: (Human) Q99448
Entrez Gene ID: (Human) 2525
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.