Proteintech

FUT8 Monoclonal Antibody (2F7H2)

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FUT8 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 66118-1-Ig (FUT8 Antibody) at dilution of 1:400 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

FUT8 Antibody in Western Blot (WB) — PC-3 cells were subjected to SDS PAGE followed by western blot with 66118-1-Ig (FUT8 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

66118-1-IG

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 2 publications 2 publications
Immunohistochemistry (IHC)	-	View 1 publication 1 publication
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Miscellaneous PubMed (Misc)	-	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human
Published species	Human
Host/Isotype	Mouse / IgG2a
Class	Monoclonal
Type	Antibody
Clone	2F7H2
Immunogen	FUT8 Fusion Protein Ag18769 (276-575 aa encoded by BC025385) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1.07 mg/mL
Purification	Protein A
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: HWSGEVKDK NVQVVEFPIV DSLHPRPPYL PLAVPEDLAD RLVRVHGDPA VWWVSQFVKY LIRPQPWLEK EIEEATKKLG FKHPVIGVHV RRTDKVGTEA AFHPIEEYMV HVEEHFQLLA RRMQVDKKRV YLATDDPSLL KEAKTKYPNY EFISDNSISW SAGLHNRYTE NSLRGVILDI HFLSQADFLV CTFSSQVCRV AYEIMQTLHP DASANFHSLD DIYYFGGQNA HNQIAIYAHQ PRTADEIPME PGDIIGVAGN HWDGYSKGVN RKLGRTGLYP SYKVREKIET VKYPTYPEAE K (276-575 aa encoded by BC025385)

Target Information

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Glycomic Profiling Highlights Increased Fucosylation in Pseudomyxoma Peritonei.

Molecular & cellular proteomics : MCP

Saarinen L,Nummela P,Leinonen H,Heiskanen A,Thiel A,Haglund C,Lepistö A,Satomaa T,Hautaniemi S,Ristimäki A

Thu Nov 01 00:00:00 EDT 2018

Biallelic Mutations in FUT8 Cause a Congenital Disorder of Glycosylation with Defective Fucosylation.

American journal of human genetics

Ng BG,Xu G,Chandy N,Steyermark J,Shinde DN,Radtke K,Raymond K,Lebrilla CB,AlAsmari A,Suchy SF,Powis Z,Faqeih EA,Berry SA,Kronn DF,Freeze HH

Thu Jan 04 00:00:00 EST 2018

A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis.

Cancer cell

Agrawal P,Fontanals-Cirera B,Sokolova E,Jacob S,Vaiana CA,Argibay D,Davalos V,McDermott M,Nayak S,Darvishian F,Castillo M,Ueberheide B,Osman I,Fenyö D,Mahal LK,Hernando E

Mon Jun 12 00:00:00 EDT 2017

Altered fucosyltransferase expression in the superior temporal gyrus of elderly patients with schizophrenia.

Schizophrenia research

Mueller TM,Yates SD,Haroutunian V,Meador-Woodruff JH

Sat Apr 01 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: Alpha-(1,6)-fucosyltransferase; Alpha1-6FucT; EC 2.4.1.68; Fucosyltransferase 8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; MGC26465

Gene Aliases: FUT8

UniProt ID: (Human) Q9BYC5

Entrez Gene ID: (Human) 2530

Molecular Function: glycosyltransferase