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Product Details
66118-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2F7H2
Immunogen
FUT8 Fusion Protein Ag18769 (276-575 aa encoded by BC025385)
Conjugate
Form
Liquid
Concentration
1.07 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: HWSGEVKDK NVQVVEFPIV DSLHPRPPYL PLAVPEDLAD RLVRVHGDPA VWWVSQFVKY LIRPQPWLEK EIEEATKKLG FKHPVIGVHV RRTDKVGTEA AFHPIEEYMV HVEEHFQLLA RRMQVDKKRV YLATDDPSLL KEAKTKYPNY EFISDNSISW SAGLHNRYTE NSLRGVILDI HFLSQADFLV CTFSSQVCRV AYEIMQTLHP DASANFHSLD DIYYFGGQNA HNQIAIYAHQ PRTADEIPME PGDIIGVAGN HWDGYSKGVN RKLGRTGLYP SYKVREKIET VKYPTYPEAE K (276-575 aa encoded by BC025385)
Target Information
Alpha-(1,6)-fucosyltransferase (FUT8) is a gene located on chromosome 14q23.3, encoding an enzyme that catalyzes the addition of fucose to N-glycans via alpha-1,6-linkage. This fucosylation is important in modifying glycoproteins, influencing their function, stability, and interactions within biological systems. FUT8 activity is crucial in various physiological processes, including immune regulation, cell signaling, and development. Aberrant fucosylation patterns, due to altered FUT8 expression, have been associated with pathological conditions such as cancer and inflammatory diseases. In oncology, FUT8-mediated core fucosylation of glycoproteins is linked to tumor progression, metastasis, and therapeutic resistance, making it a potential biomarker for cancer diagnosis and prognosis. Additionally, FUT8's role in immune function highlights its involvement in cellular communication and homeostasis, offering insights into therapeutic strategies aimed at modulating glycosylation pathways to address disease states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alpha-(1,6)-fucosyltransferase; Alpha1-6FucT; EC 2.4.1.68; Fucosyltransferase 8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; MGC26465
Gene Aliases: FUT8
UniProt ID: (Human) Q9BYC5
Entrez Gene ID: (Human) 2530
in utero embryonic development
protein N-linked glycosylation
N-glycan processing
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
respiratory gaseous exchange
oligosaccharide biosynthetic process
regulation of gene expression
cell migration
protein N-linked glycosylation via asparagine
protein glycosylation in Golgi
N-glycan fucosylation
L-fucose catabolic process
receptor metabolic process
GDP-L-fucose metabolic process
regulation of cellular response to oxidative stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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