FXYD3 belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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Protein Aliases: Chloride conductance inducer protein Mat-8; FXYD domain-containing ion transport regulator 3; FXYD3; Mammary tumor 8 kDa protein; MAT8; Phospholemman-like; phospholemman-like protein; PLML; Sodium/potassium-transporting ATPase subunit FXYD3
Gene Aliases: FXYD3; MAT8; PLML
UniProt ID: (Human) Q14802
Entrez Gene ID: (Human) 5349