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Abnova
FZD7 Monoclonal Antibody (4D9)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
H00008324-M03
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
4D9
Immunogen
FZD7 (NP_003498.1, 155 a.a. approximately 253 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: GAGEICVGQN TSDGSGGPGG GPTAYPTAPY LPDLPFTALP PGASDGRGRP AFPFSCPRQL KVPPYLGYRF LGERDCGAPC EPGRANGLMY FKEEERRFA
Target Information
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: frizzled 7, seven transmembrane spanning receptor; frizzled family receptor 7; frizzled homolog 7; Frizzled, drosophila, homolog of, 7; fz-7; hFz7; rizzled 7
Gene Aliases: FzE3
UniProt ID: (Human) O75084
Entrez Gene ID: (Human) 8324
regulation of transcription, DNA-templated
cell surface receptor signaling pathway
negative regulation of cell-substrate adhesion
stem cell population maintenance
neuron differentiation
non-canonical Wnt signaling pathway
positive regulation of phosphorylation
negative regulation of ectodermal cell fate specification
positive regulation of MAPK cascade
positive regulation of transcription, DNA-templated
positive regulation of JNK cascade
positive regulation of epithelial cell proliferation involved in wound healing
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
mesenchymal to epithelial transition
regulation of canonical Wnt signaling pathway
cellular response to retinoic acid
negative regulation of cardiac muscle cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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