|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG|
|Immunogen||120kD activation peptide of human factor V.|
|Purification||Ion-exchange chromatography, Ammonium sulfate precipitation|
|Storage buffer||50% water with 50% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Radioimmune Assays (RIA)||5-10 µg/mL|
|Western Blot (WB)||5 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-43001 detects Factor V in human samples.
MA1-43001 has successfully been used in RIA and Western blot applications.
MA1-43001 was derived from the 120kD activation peptide of human factor V.
Coagulation factor V (or Proaccelerin) is an essential factor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The active factor V is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in the Factor V gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.