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|Tested species reactivity||Mouse|
|Host / Isotype||Rat|
|Immunogen||Mouse Factor VIII.|
|Purification||Ion-exchange chromatography, Ammonium sulfate precipitation|
|Storage buffer||50% water with 50% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ELISA (ELISA)||5-10 µg/mL|
|Western Blot (WB)||5-10 µg/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-43037 detects Factor VIII in mouse samples.
MA1-43037 has successfully been used in Western blot and ELISA applications.
MA1-43037 was derived from mouse factor VIII.
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
AHF; Coagulation factor 8; coagulation factor VIII; F8; Factor VIII; HEMA; procoagulant component
Cf-8; Cf8; F8; F8c; FVIII