MA1-10589 detects full-length human Factor VIII. This antibody does not cross-react with von Willebrand factor.
MA1-10589 has been successfully used in ELISA and Western blot applications.
The MA1-10589 immunogen is purified human Factor VIII.
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AHF; Antihemophilic factor; Coagulation factor VIII; coagulation factor VIII A1 domain; coagulation factor VIII C2 domain; coagulation factor VIII, procoagulant component; coagulation factor VIIIc; DXS1253E; F8B; F8C; Factor VIII B chain; factor VIII F8B; Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIIIa light chain; FVIII; HEMA; Procoagulant component; RP11-115M6.7
Gene Aliases: AHF; DXS1253E; F8; F8B; F8C; FVIII; HEMA
UniProt ID: (Human) P00451
Entrez Gene ID: (Human) 2157
Molecular Function: apolipoprotein cell adhesion molecule enzyme modulator extracellular matrix protein hydrolase membrane-bound signaling molecule metalloprotease oxidase oxidoreductase protease receptor serine protease signaling molecule transfer/carrier protein transporter