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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Full length native protein (purified) (Human).|
|Storage buffer||PBS, pH 7.4|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-90302 detects Factor XII Heavy chain from human samples.
MA1-90302 has been successfully used in Western blot and ELISA applications.
The MA1-90302 immunogen is: Full length native protein (purified) (Human).
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
beta-factor XIIa part 1; beta-factor XIIa part 2; coagulation factor XII (Hageman factor); coagulation factor XIIa heavy chain; coagulation factor XIIa light chain; HAE3; HAEX; HAF; Hageman factor
F12; HAE3; HAEX; HAF