MA5-11751 targets Factor XIII A in IHC (P) and WB applications and shows reactivity with Human samples.
The MA5-11751 immunogen is recombinant protein corresponding to A-subunit of coagulation Factor XIII.
Factor XIII in both reduced and non-reduced forms. It does not react with human Factor XIII B-chain or human Factor XII. Factor XIII is a beta-globulin found in plasma and is composed of two subunits. Factor XIII-A is the catalytic subunit and is a dimer of M.W. 160kDa. Factor XIII is present in plasma as an alpha2beta2 heterodimer (M.W. 320kDa); whereas in platelets, only the alpha2 unit exists. Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system. Factor XIII has also been used with CD34 to differentiate between dermatofibroma and dermatofibrosarcoma protuberans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A polypeptide; A subunit; A1 polypeptide); bA525O21.1 (coagulation factor XIII; bA525O21.1 (coagulation factor XIII, A1 polypeptide); coagulation factor XIII; Coagulation factor XIII A chain; coagulation factor XIII, A polypeptide; coagulation factor XIII, A1 polypeptide; Coagulation factor XIIIa; factor XIIIa; fibrin stabilizing factor; fibrin stabilizing factor, A subunit; fibrinoligase; FSF; FSF, A subunit; Protein-glutamine gamma-glutamyltransferase A chain; TGase; Transglutaminase A chain; transglutaminase. plasma
Gene Aliases: F13A; F13A1
UniProt ID: (Human) P00488
Entrez Gene ID: (Human) 2162