|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Non-human primate, Human, Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Fascin purified from HeLa cells|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:200|
|Western Blot (WB)||1:250|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-11483 targets Fascin in IHC (P) applications and shows reactivity with Human and Rat samples.
The MA5-11483 immunogen is fascin purified from HeLa cells.
Human fascin is a highly conserved actin-bundling protein. Fascin, encoded by the human homolog for sn (hsn) gene, has been localized to microspikes and stress fibers of cultured cells where it is thought to be involved in the formation of microfilament bundles. It is expressed predominantly in dendritic cells. Lymphoid cells, myeloid cells and plasma cells are negative. However. Reed Sternberg cells in Hodgkin's lymphoma are positive for fascin staining. Epstein-Barr virus may induce expression of fascin in B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Association of Fascin and matrix metalloproteinase-9 expression with poor prognostic parameters in breast carcinoma of Egyptian women.
MA5-11483 was used in immunohistochemistry - paraffin section to study breast carcinoma in Egyptian women and poor prognosis if Fascin and matrix metalloproteinase-9 expression are associated
|Youssef NS,Hakim SA||Diagnostic pathology (9:null)||2014|
The correlation of cortactin and fascin-1 expression with clinicopathological parameters in pancreatic and ampulla of Vater adenocarcinoma.
MA5-11483 was used in immunohistochemistry to study the clinicopathology of pancreatic and ampulla of Vater adenocarcinomas and the corresponding expression of cortactin and fascin-1
|Tsai WC,Lin CK,Lee HS,Gao HW,Nieh S,Chan DC,Jin JS||APMIS : acta pathologica, microbiologica, et immunologica Scandinavica (121:171)||2013|
Fascin expression and its potential significance in gastrointestinal stromal tumors.
MA5-11483 was used in immunohistochemistry to study the expression of fascin in gastrointestinal stromal tumors and its possible prognostic value
|Ozcan A,Karslio¿lu Y,Günal A,Cerm¿k AH,Kurt B,Ongürü O||The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology (22:363)||2011|
EGFR signaling regulates tumor cell migration in craniopharyngiomas.
MA5-11483 was used in immunohistochemistry and western blot to study the role of EGFR signaling in regulating tumor cell migration in craniopharyngiomas
|Hölsken A,Gebhardt M,Buchfelder M,Fahlbusch R,Blümcke I,Buslei R||Clinical cancer research : an official journal of the American Association for Cancer Research (17:4367)||2011|
Prognostic significance of fascin-1 and E-cadherin expression in laryngeal squamous cell carcinoma.
MA5-11483 was used in immunohistochemistry to study the prognostic significance of fascin-1 and E-cadherin expression in laryngeal squamous cell carcinoma
|Zou J,Yang H,Chen F,Zhao H,Lin P,Zhang J,Ye H,Wang L,Liu S||European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) (19:11)||2010|
|Non-human primate||Not Cited||
Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys.
MA5-11483 was used in immunohistochemistry to study the role of CD4+ T-cells in determining the viral load set-point in sooty mangabeys naturally infected with SIV
|Klatt NR,Villinger F,Bostik P,Gordon SN,Pereira L,Engram JC,Mayne A,Dunham RM,Lawson B,Ratcliffe SJ,Sodora DL,Else J,Reimann K,Staprans SI,Haase AT,Estes JD,Silvestri G,Ansari AA||The Journal of clinical investigation (118:2039)||2008|
Proteomic identification of novel proteins in cortical lewy bodies.
MA5-11483 was used in immunohistochemistry to identify novel proteins in cortical lewy bodies using proteomics
|Leverenz JB,Umar I,Wang Q,Montine TJ,McMillan PJ,Tsuang DW,Jin J,Pan C,Shin J,Zhu D,Zhang J||Brain pathology (Zurich, Switzerland) (17:139)||2007|