|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Region of Fc epsilonR1 alpha which overlaps with the IgE binding site.|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay dependent|
|Immunohistochemistry (IHC)||Assay dependent|
|Western Blot (WB)||1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-4998 detects Fc epsilonR1 alpha from human samples. The CRA2 (AER24) monoclonal antibody reacts with the Fc epsilonR1 alpha subunit on a region that overlaps the region of the IgE binding site, thus it competes with IgE for the receptor binding. Since
MA1-4998 has been successfully used in Western blot, flow cytometry, and immunohistochemistry applications.
The MA1-4998 immunogen is region of Fc epsilonR1 alpha which overlaps with the IgE binding site.
Fc epsilonR1 alpha is a subunit of the high affinity receptor of IgE to which it directly binds. Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one ß and two additional subunits. The latter two are required for signal transduction activity. The Fc epsilonR1 complex plays an important role in triggering allergic responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.