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|Tested species reactivity||Human|
|Host / Isotype||Duck / IgY|
|Immunogen||Purified human liver ferritin|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.02M MES, pH 5.8, with 0.14M NaCl|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunodiffusion (IDF)||Assay Dependent|
|Immunoelectrophoresis (IE)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Purity: IgY Fc is >90% total protein by SDS-PAGE, and total immunoglobulin is >95% total protein.
Ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis. It is a holoenzyme shell (~450 kDa) consisting of 24 subunits of two types, H(heavy) and L(light), and capable of storing up to 4,500 atoms of ferric iron. Depending on the tissue type and physiologic status of the cell, the ratio of H to L subunits in ferritin can vary widely. It can be viewed not only as part of a group of iron regulatory proteins that include transferrin and the transferrin receptor, but also as a member of the protein family that orchestrates the cellular defense against stress and inflammation. Ferritin is found in the liver, spleen, kidney and heart. Only a small amount is found in the blood. The blood level of ferritin serves as an indicator of the amount of iron stored in the body. The highest concentration of ferritin is in liver parenchymal cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ferritin L subunit; ferritin L-chain; ferritin light chain; ferritin light polypeptide-like 3; MGC71996