Immunogen sequence: VKAGLKEEET ELKQLNLHKD TEPKPLEGTH LMGVKDSNIH ELEHEQEPTC ASQMAEPFRT FRDGWVSYYN
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 86%.
SLC40A1 is an iron-regulated transporter assumed to play roles in intestinal iron absorption and cellular iron release. It mediates iron efflux in the presence of ferroxidase. Defects in SLC40A1 cause hemochromatosis type 4 (HFE4), which is an autosomal dominant iron-loading disorder.
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Protein Aliases: ferroportin 1; Ferroportin-1; FPN1; HFE4; IREG1; iron regulated gene 1; Iron-regulated transporter 1; member 3; MST079; MSTP079; putative ferroportin 1 variant IIIB; SLC11A3; solute carrier family 11 (proton-coupled divalent metal ion transporters); solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3; solute carrier family 40 (iron-regulated transporter), member 1; Solute carrier family 40 member 1
Gene Aliases: FPN1; HFE4; IREG1; MST079; MSTP079; MTP1; SLC11A3; SLC40A1
UniProt ID: (Human) Q9NP59
Entrez Gene ID: (Human) 30061