|Flow Cytometry (Flow)||Assay-Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human Fetal Hemoglobin (HbF)|
|Storage buffer||PBS with <10% sucrose, BSA|
|Contains||0.1% sodium azide|
|Storage conditions||4° C, store in dark|
R-phycoerythrin (PE) is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients.
This antibody specifically recognizes fetal hemoglobin found in fetal erythrocytes.
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.
Class 2 Device
Protein Aliases: A-gamma globin; alpha-1 globin; gamma A hemoglobin; gamma globin; Gamma-1-globin; Hb F Agamma; HBG1; hemoglobin alpha 1; Hemoglobin gamma-1 chain; Hemoglobin gamma-A chain; hemoglobin subunit alpha; Hemoglobin subunit gamma-1; hemoglobin, gamma A; hemoglobin, gamma, regulator of
Gene Aliases: HBG-T2; HBG1; HBGA; HBGR; HSGGL1; PRO2979
UniProt ID: (Human) P69891
Entrez Gene ID: (Human) 3047
Molecular Function: transfer/carrier protein
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