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|Tested species reactivity||Human, Mouse, Primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide surrounding pThr298 of human fibrillarin|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Contains||<0.02% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
It is not recommended to aliquot this antibody.
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
34 kDa nucleolar scleroderma antigen; 34-kD nucleolar scleroderma antigen; histone-glutamine methyltransferase; nucleolar protein 1; RNA, U3 small nucleolar interacting protein 1; rRNA 2'-O-methyltransferase fibrillarin
AL022665; FBL; FIB; FIB1; FLRN; RNU3IP1