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Invitrogen

Fibrillarin/FBLL1 Recombinant Rabbit Monoclonal Antibody (HL2588)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-56708

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL2588

Immunogen

Recombinant fragment of human fibrillarin.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3679734

Target Information

Fibrillarin, encoded by the FBL gene (also known as FBLL1), is a highly conserved nucleolar protein that plays a critical role in the biogenesis of ribosomes. It is a component of the small nucleolar ribonucleoprotein (snoRNP) complexes and is primarily involved in the chemical modification of ribosomal RNA (rRNA), specifically in the methylation of the 2'-O-ribose residues of rRNA. This modification is essential for the proper processing and maturation of pre-rRNA into functional ribosomal subunits, which are crucial for protein synthesis within the cell. Fibrillarin is not only important for ribosome production but also for maintaining the structural integrity of the nucleolus, the site of ribosome assembly. Dysregulation or mutations in the FBL gene have been associated with various human diseases, including cancer, where altered ribosome biogenesis can contribute to uncontrolled cell proliferation. Additionally, fibrillarin has been studied in the context of autoimmune diseases, such as systemic sclerosis, where it can serve as an autoantigen. Understanding the function and regulation of fibrillarin is vital for insights into cellular growth, protein synthesis, and the pathogenesis of related diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 34 kDa nucleolar scleroderma antigen; 34-kD nucleolar scleroderma antigen; Histone-glutamine methyltransferase; Nucleolar protein 1; Protein-glutamine methyltransferase; RNA, U3 small nucleolar interacting protein 1; rRNA 2'-O-methyltransferase fibrillarin; rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; U6 snRNA 2'-O-methyltransferase fibrillarin

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Gene Aliases: AI595406; AL022665; FBL; Fbll1; FIB; FIB1; FLRN; RGD1562841; RNU3IP1

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UniProt ID: (Human) P22087, (Rat) P22509, (Mouse) P35550, (Mouse) Q80WS3

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Entrez Gene ID: (Human) 2091, (Rat) 292747, (Mouse) 14113, (Mouse) 237730, (Rat) 363563

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Function(s)
TFIID-class transcription factor binding RNA binding protein binding rRNA methyltransferase activity poly(A) RNA binding ATPase binding histone-glutamine methyltransferase activity rRNA (adenine-N6,N6-)-dimethyltransferase activity protein C-terminal carboxyl O-methyltransferase activity tRNA (guanine-N2-)-methyltransferase activity methyltransferase activity C-methyltransferase activity N-methyltransferase activity O-methyltransferase activity S-methyltransferase activity RNA methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity protein methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity rRNA (adenine-N6-)-methyltransferase activity DNA-methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity selenocysteine methyltransferase activity arginine N-methyltransferase activity protein-arginine N-methyltransferase activity lysine N-methyltransferase activity protein-lysine N-methyltransferase activity tRNA (uracil) methyltransferase activity tRNA (guanine) methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (cytosine) methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity rRNA (adenine) methyltransferase activity rRNA (cytosine) methyltransferase activity rRNA (guanine) methyltransferase activity rRNA (uridine) methyltransferase activity transferase activity protein C-terminal leucine carboxyl O-methyltransferase activity 1-phenanthrol methyltransferase activity protein-arginine N5-methyltransferase activity methylarsonite methyltransferase activity dimethylarsinite methyltransferase activity 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 1-hydroxypyrene methyltransferase activity 1-hydroxy-6-methoxypyrene methyltransferase activity demethylmenaquinone methyltransferase activity cobalt-precorrin-6B C5-methyltransferase activity cobalt-precorrin-7 C15-methyltransferase activity cobalt-precorrin-5B C1-methyltransferase activity cobalt-precorrin-3 C17-methyltransferase activity dimethylamine methyltransferase activity hydroxyneurosporene-O-methyltransferase activity tRNA (adenine-57, 58-N(1)-) methyltransferase activity methylamine-specific methylcobalamin:coenzyme M methyltransferase activity trimethylamine methyltransferase activity methanol-specific methylcobalamin:coenzyme M methyltransferase activity monomethylamine methyltransferase activity P-methyltransferase activity Se-methyltransferase activity 2-phytyl-1,4-naphthoquinone methyltransferase activity tRNA (uracil-2'-O-)-methyltransferase activity tRNA (cytosine-2'-O-)-methyltransferase activity phosphomethylethanolamine N-methyltransferase activity tRNA (cytosine-3-)-methyltransferase activity rRNA (cytosine-2'-O-)-methyltransferase activity rRNA (cytosine-N4-)-methyltransferase activity trihydroxyferuloyl spermidine O-methyltransferase activity RNA processing factor
Process(es)
box C/D snoRNA 3'-end processing osteoblast differentiation rRNA processing tRNA processing rRNA methylation snoRNA localization histone glutamine methylation RNA processing snoRNA metabolic process methylation
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