Invitrogen
MA5-12770 targets Fibrillin-1 in ICC/IF, IHC (F), IM, and WB applications and shows reactivity with Bovine and Human samples.
The MA5-12770 immunogen is microfibrils from zonular apparatus of bovine eye.
Fibrillin 1 is an extracellular acidic protein with a high cysteine content and an extended thread-like shape with mosaic composition of different types of extracellular modules. Most of the fibrillin molecule is contributed by 47 epidermal growth factor-like (EGF-like) repeats; 43 of them have a consensus sequence for calcium binding (cb). Other modules including 8-cysteine motifs (seven), hybrid motifs (two), and unique domains (three) are interspersed throughout the molecule[3-7]. Fibrillin 1 contains a proline-rich region close to the N-terminus that is replaced by a glycine-rich region in Fibrillin 2. The fibrillins are found throughout the connective tissue as integral components of extended fibrils.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Asprosin; fibrillin 15; Fibrillin-1; MP340; putative
Gene Aliases: ACMICD; ECTOL1; FBN; FBN1; GPHYSD2; MASS; MFLS; MFS1; OCTD; SGS; SSKS; WMS; WMS2
UniProt ID: (Human) P35555
Entrez Gene ID: (Human) 2200, (Bovine) 281154
Molecular Function:
annexin
calcium-binding protein
calmodulin
cell adhesion molecule
extracellular matrix glycoprotein
extracellular matrix protein
extracellular matrix structural protein
intracellular calcium-sensing protein
signaling molecule
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