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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Fibrin degradation products.|
|Storage buffer||PBS, pH 7.2|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay dependent|
|Western Blot (WB)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-20040 detects fibrinogen in human samples.
MA1-20040 has been successfully used in ELISA and Western blot procedures.
The MA1-20040 immunogen is fibrin degradation products.
Fibrinogen is the main protein of blood coagulation system. It is a large protein (MW 340 kDa) and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1-16 amino acids) and B (1-17 amino acids) are released by thrombin from the N-terminal parts of alpha- and beta-chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Fib2; Fibrinogen alpha chain; fibrinogen, A alpha polypeptide; MGC119422; MGC119423; MGC119425