|Tested species reactivity||Bovine, Human, Sheep|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human and bovine lens filament enriched fraction (plasma membrane cytoskeleton complex).|
|Storage buffer||whole serum|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-25031 detects Filensin from human, bovine, and ovine samples. MA1-25031 will not react with mouse, rat, or chicken.
MA1-25031 has been successfully used in Western blot procedures.
The MA1-25031 immunogen is human and bovine lens filament enriched fraction (plasma membrane cytoskeleton complex).
More than 99% of the vertebrate ocular lens is comprised of terminally differentiated lens fiber cells. Two lens-specific intermediate filament-like proteins, CP49 (also known as phakinin) and the protein product of this gene, filensin, are expressed only after fiber cell differentiation has begun. Both proteins are found in a structurally unique cytoskeletal element that is referred to as the beaded filament (BF). Mutations in this gene are the cause of autosomal recessive cortical juvenile-onset cataract. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.